Use of Restricted Significance Tests in Clinical Trials

Inbunden, Engelska, 1992

Av David S. Salsburg

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This thought-provoking book discusses the use of statistics in randomized clinical trials. Its aim is two-fold: firstly, it presents a clear account of the design and analysis of experiments in this setting which stresses the foundational issues involved. Secondly, the book seeks to develop the specific tools of analysis which can be derived from Neyman's model of restricted tests. The book is based on the author's many years of experience of clinical trials. Throughout, examples are used from a variety of types of study. As a result, all statisticians and research scientists who work on clinical trials will find this presentation clear and accessible, and very relevant to their own research interests.

Produktinformation

Utgivningsdatum1992-08-06
Mått155 x 235 x 15 mm
Vikt453 g
FormatInbunden
SpråkEngelska
SerieStatistics for Biology and Health
Antal sidor174
Upplaga1992
FörlagSpringer-Verlag New York Inc.
ISBN9780387977980

Tillhör följande kategorier

One Philosophical and Scientific Problems when Applying Statistical Methods to Clinical Data.- 1 The Randomized Controlled Clinical Trial.- 2 Probability Models and Clinical Medicine.- 3 Significance Tests Versus Hypothesis Tests.- 4 Neyman’s Insights.- 5 Reconciling Fisher and Neyman.- Two Techniques for Applying Restricted Tests to Data from Randomized Controlled Clinical Trials.- 6 Continuous Measures Taken over Time.- 7 Combining Data Across Measures.- 8 Counts of Events.- 9 Permutation Tests and Resampling Techniques.- 10 Neyman’s Restricted Chi Square Tests.- 11 Miscellaneous Methods for Increasing Power.- 12 Bayesian Estimation.- 13 An Example of the Type of Analysis Suggested in This Book.- References.