Use of Restricted Significance Tests in Clinical Trials

• One Philosophical and Scientific Problems when Applying Statistical Methods to Clinical Data.- 1 The Randomized Controlled Clinical Trial.- 2 Probability Models and Clinical Medicine.- 3 Significance Tests Versus Hypothesis Tests.- 4 Neyman’s Insights.- 5 Reconciling Fisher and Neyman.- Two Techniques for Applying Restricted Tests to Data from Randomized Controlled Clinical Trials.- 6 Continuous Measures Taken over Time.- 7 Combining Data Across Measures.- 8 Counts of Events.- 9 Permutation Tests and Resampling Techniques.- 10 Neyman’s Restricted Chi Square Tests.- 11 Miscellaneous Methods for Increasing Power.- 12 Bayesian Estimation.- 13 An Example of the Type of Analysis Suggested in This Book.- References.

"...A broad range of statistical methodologies is surveyed including restricted chi-square tests, normal theory tests, nonparametric tests, permutation and resampling methods and Bayesian estimation...For anyone who wants to think deeply about the basic issues involving the design and analysis of clinical trials, this book is a must read.."(Zentralblatt fur Mathematik)