Tumor Suppressor Par-4

Structural Features, Molecular Mechanisms and Function

Inbunden, Engelska, 2022

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Par-4 is a tumor suppressor protein first discovered and identified in 1993 by Dr. Vivek Rangnekar’s laboratory in prostate cancer cells undergoing apoptosis.

Produktinformation

Utgivningsdatum2022-01-09
Mått155 x 235 x 24 mm
Vikt670 g
FormatInbunden
SpråkEngelska
Antal sidor323
FörlagSpringer Nature Switzerland AG
ISBN9783030735715

Tillhör följande kategorier

Onkologi inom Medicin
Medicinsk utrustning och medicinska tekniker inom Medicin
Biokemi inom Naturvetenskap och teknik
Klinisk medicin och internmedicin inom Medicin

Vivek M. Rangnekar, Ph.D. is Professor and Alfred Cohen Chair in Oncology Research in the Department of Radiation Medicine and Associate Director of the Markey Cancer Center at the University of Kentucky. His laboratory studies the molecular cross-talk between oncogenes and tumor suppressor genes in an effort to tilt the balance in favor of tumor suppressor function. Dr. Rangnekar originally discovered and identified the tumor suppressor protein Par-4/PAWR in 1993.

Discovery and Overview of Par-4.- Par-4 in cell cycle regulation.- Conformational studies of the Par-4 C-terminal Domain.- Structural analysis of Par-4 and crystallographic analysis of the regulatory domain.- Regulation of Par-4 by Ubiquitinases.- REGULATION OF PAR-4 FUNCTION BY PHOSPHORYLATION.- Role of Par-4 in GRP78 translocation.- PAR-4 in the regulation of stem cell death and embryo development.- RASSF2 and the PAR-4 connection.- Regulation of tumor suppressor Par-4 by ceramide.- PAWR as a direct SRC-1/HOXC11 suppression target.- Index.