Transforming Growth Factor-Beta in Cancer Therapy, Volume II
Cancer Treatment and Therapy
Inbunden, Engelska, 2008
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Fri frakt för medlemmar vid köp för minst 249 kr.Transforming Growth Factor-B in Cancer Therapy, Volume II: Cancer Treatment and Therapy The chapters in this volume confer an abundance of knowledge about the current state ofour understanding oftransforming growth factor-B (TGF-B) in cancer treatment and therapy. Unlike several more traditional positive polypeptide growth factors that stim ulate cellular proliferation, the prototypical TGF-B is now known to inhibit the growth of most normal cell types, including those of epithelial and mesenchymal origin. However, there are examplesofcell types that can be stimulated by TGF-B under certain conditions. TGF-B also induces the accumulation of matrix molecules by stimulating their synthesis as well as inhibiting their degradation. Moreover, TGF-B induces apoptosis of certain cell types, thereby restricting their proliferation. OveractivityofTGF-~ has been linked to several diseases. For instance, the effect ofTGF-~ on matrix accumulation contributes to fibrotic conditions, like glomerulonephritis, lung fibrosis and liver cirrhosis (1). TGF-~ has a very complicated role in cancer that is only beginning to be understood.
Produktinformation
- Utgivningsdatum2008-02-28
- Mått178 x 254 x 48 mm
- Vikt1 702 g
- FormatInbunden
- SpråkEngelska
- SerieCancer Drug Discovery and Development
- Antal sidor786
- Upplaga2008
- FörlagHumana Press Inc.
- MedarbetareHeldin,C.-H.
- ISBN9781588297150