Transcriptomics in Atherosclerosis

Deciphering Molecular Signatures and Advancing Therapeutic Strategies

Häftad, Engelska, 2025

Av Yvan Devaux, Miron Sopic, Miron Sopić, Luxembourg) Devaux, Yvan, PhD (Luxembourg Institute of Health, University of Belgrade) Sopic, Miron, PhD (Faculty of Pharmacy

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Transcriptomics in Atherosclerosis: Deciphering Molecular Signatures and Advancing Therapeutic Strategies explores how transcriptomic research is transforming our understanding and management of atherosclerosis. Bridging molecular biology and clinical medicine, it delves into the dynamic regulation of gene expression, the role of non-coding RNAs, and emerging insights from epitranscriptomics.

The book emphasizes advanced technologies such as single-cell and spatial transcriptomics, while embracing systems-level integration with other omic layers. It highlights how these approaches can reveal disease mechanisms, refine risk stratification, and guide the development of RNA-based diagnostics and therapies.

Designed for researchers, clinicians, and translational scientists, this volume moves beyond generic overviews to present current methods, practical insights, and real-world challenges in the field. By doing so, it lays the groundwork for a new generation of precision strategies in cardiovascular care.

Unravels the molecular complexity of atherosclerosis using the latest transcriptomic technologies, offering new perspectives on disease mechanisms and potential therapeutic targets
Highlights the transformative potential of RNA molecules in advancing diagnostics and developing novel RNA-based treatments for personalized medicine in cardiovascular care
Provides actionable insights into translating transcriptomic findings into clinical applications, enhancing patient stratification and treatment strategies

Produktinformation

Utgivningsdatum2025-10-27
Mått191 x 235 x 20 mm
Vikt450 g
FormatHäftad
SpråkEngelska
Antal sidor403
FörlagElsevier Science
ISBN9780443330643

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Hjärt- och kärlsjukdomar inom Medicin
Biologi inom Naturvetenskap och teknik

Yvan Devaux, Ph.D. explores the frontiers of RNA biology in cardiovascular and neurological disease. With a translational, patient-centered approach, his work bridges disciplines—uniting clinicians, computational biologists, researchers, and industry partners to address urgent medical needs. Devaux’s team has pioneered biomarker discovery pipelines using deep sequencing, AI, and advanced bioinformatics. A seasoned leader of large-scale research consortia, he now focuses on the heart-brain axis, uncovering RNA biomarkers that illuminate the complex interplay between brain and heart disease. This volume captures his vision for collaborative, data-driven innovation in precision medicine.Miron Sopić, Ph.D. is an Associate Professor of Medical Biochemistry at the Faculty of Pharmacy, University of Belgrade. He teaches biochemistry with a strong emphasis on its diagnostic applications, grounded in his scientific expertise. His research centers on inflammation in cardiometabolic diseases, particularly the discovery of RNA-based biomarkers. Dr. Sopić is the author of more than 54 scientific publications and was awarded the Marie Skłodowska-Curie Postdoctoral Fellowship in 2022. This fellowship enabled his collaboration with Dr. Yvan Devaux at the Luxembourg Institute of Health, where they are exploring epitranscriptomic signatures in atherosclerosis—pushing the boundaries of cardiovascular molecular medicine.

Section I – Introduction1. Atherosclerotic CVD – epidemiology and current challenges in management2. Atherosclerotic Plaque Phenotypes: Unraveling Complexity and HeterogeneitySection II – The role of RNAs in atherosclerosis progression and development3. Biogenesis and mechanisms of action of ncRNAs4. The role of ncRNA in plaque development and progression5. Signaling Pathways Regulating Gene Expression in Atherosclerosis6. Epitranscriptomics and Atherosclerosis:Section III – Transcriptomic Profiling of Atherosclerotic Lesions7. Essentials of Transcriptomic Methods: Navigating Through RNA Sequencing and Beyond8. Bridging the Gap in Transcriptomics: From Animal to Human Studies in Atherosclerosis9. Translating Transcriptomics into Clinical Practice: Utilizing Gene Expression Patterns for Advanced Patient Phenotyping and Stratification in Atherosclerosis Optimizing Study Design for In-depth Transcriptomic Analysis of Atherosclerotic Plaques10. Unveiling Sex-Specific Transcriptomic Mechanisms in AtherosclerosisSection IV – Integrating Multi-Omics Approaches in Atherosclerosis Research11. Combining Transcriptomics with Genomics, Proteomics, and Metabolomics12. Insights into Gene Regulatory Networks in Vascular Pathology13. Systems Biology and Network Analysis14. Use of artificial intelligence and machine learning for multi-omicsSection V – RNA-Based Theranostics: Revolutionizing Treatment and Diagnosis in Atherosclerotic Cardiovascular Disease15. RNA Therapeutics in Atherosclerosis:16. RNA Therapeutic Delivery Systems – advances and challenges17. Exploring Circulating RNAs: Emerging Biomarkers for Atherosclerosis Detection and MonitoringSection VI – Conclusion18. Future Directions and Emerging Technologies in Transcriptomic Research and Atherosclerosis