Trafficking of GPCRs

Dr. Guangyu Wu, the editor of this book, is a professor in the Department of Pharmacology and Toxicology at the Medical College of Georgia, Georgia Regents University. The long term goal of Dr. Wu’s research effort is to define the molecular mechanisms underlying the intracellular trafficking and signal propagation of GPCRs. Dr. Wu’s research at the earlier stages, as a graduate student and a post-doctoral fellow, was mainly on the GPCR pharmacology and signal transduction pathways. Since starting his own laboratory in the Department of Pharmacology at Louisiana State University Health Sciences Center New Orleans, Dr. Wu has focused his research on the regulation of GPCR export from the endoplasmic reticulum through the Golgi apparatus to the cell surface through studying the function of well-defined transport machinery at different intracellular organelles and defining specific motifs embedded within the receptors that direct receptor export from the ER/Golgi or cell surface transport.

• Arrestins: Critical Players in Trafficking of Many GPCRsVsevolod V. Gurevich and Eugenia V. GurevichRegulation of GPCR Trafficking by UbiquitinJustine E. Kennedy and Adriano MarcheseRhodopsin Trafficking and Mistrafficking: Signals, Molecular Components and MechanismsIna Nemet, Philip Ropelewski and Yoshikazu ImanishiIntracellular Trafficking of Neuropeptide Y ReceptorsKarin Mörl and Annette G. Beck-SickingerInsights into Serotonin Receptor Trafficking: Cell Membrane Targeting and InternalizationMichèle Darmon, Sana Al Awabdh , Michel-Boris Emerit and Justine Masson Calcium-Sensing Receptor: Trafficking, Endocytosis, Recycling and Importance of Interacting ProteinsKausik RayTrafficking of β Adrenergic Receptors: Implications in Intracellular Receptor SignalingQin Fu and Yang K. Xiang Post-endocytic sorting of Adrenergic and Opioid Receptors: New Mechanisms and Functions.Shanna L. Bowman and Manojkumar A. Puthenveeduα2 Adrenergic Receptor Trafficking as a Therapeutic Target in Antidepressant Drug ActionChristopher Cottingham, Craig J. Ferryman and Qin WangRegulation of α2B-Adrenerigc Receptor Export Trafficking by Specific Motifs Guangyu Wu, Jason E. Davis and Maoxiang Zhang Temperature-Sensitive Intracellular Traffic of Α2c-Adrenergic ReceptorCatalin M. FilipeanuN-Terminal Signal Peptides of G Protein-Coupled Receptors: Significance for Receptor Biosynthesis, Trafficking and Signal TransductionClaudia Rutz, Wolfgang Klein and Ralf Schülein Regulation of GPCR Anterograde Trafficking by Molecular Chaperones and Motifs Brent Young, Jaime Wertman and Denis J. Dupré