Del 579 - Methods in Enzymology

The Resolution Revolution: Recent Advances In cryoEM

Inbunden, Engelska, 2016

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cryoEM, a new volume in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods and new developments in recording images, the creation, evaluation and validation of 3D maps from the images, model building into maps and refinement of the resulting atomic structures, and applications of essentially single particle methods to helical structures and to sub-tomogram averaging.

Continues the legacy of this premier serial with quality chapters authored by leaders in the field
Covers research methods that determine the structures of biological molecules, a vital step for understanding their function
Contains the technical developments underpinning the advances of cryoEM and captures the exciting insights that have resulted

Produktinformation

Utgivningsdatum2016-08-26
Mått152 x 229 x 29 mm
Vikt910 g
FormatInbunden
SpråkEngelska
SerieDel 579 i Methods in Enzymology
Antal sidor486
FörlagElsevier Science
MedarbetareCrowther,R.A
ISBN9780128053829

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Tony Crowther is an emeritus scientist at the MRC Laboratory of Molecular Biology in Cambridge, where he was joint head of the Structural Studies Division from 1994 to 2005. He has been involved in electron microscopy and image processing of biological structures for many years. His particular biological interests have been in viruses such as hepatitis B and in the abnormal filaments that form in neurodegenerative diseases. He is a Fellow of the Royal Society of London, a Fellow of the Academy of Medical Sciences and a member of the European Molecular Biology Organization.

1. Direct Electron Detectors - Methods in Enzymology (2016)Greg McMullan, Abdul R. Faruqi and Richard Henderson2. Specimen Behavior in the Electron BeamRobert M. Glaeser3. Specimen Preparation for High-Resolution Cryo-EMChristopher J. Russo and Lori A. Passmore4. Strategies for Automated Cryoem Data Collection Using Direct Detectors Anchi Cheng, Yong Zi Tan, Venkat Dandey, Clinton S. Potter and Bridget Carragher5. Processing of Cryo-EM Movie DataZev A. Ripstein and John L. Rubinstein6. Processing of Structurally Heterogeneous Cryo-EM Data in RELIONSjors H.W. Scheres7. Single Particle Refinement and Variability Analysis in EMAN2.1Steven J. Ludtke8. Frealign: An Exploratory Tool for Single Particle Cryo-EMNikolaus Grigorieff9. Testing the Validity of Single Particle Maps at Low and High ResolutionPeter B. Rosenthal10. Tools for Model Building and Optimization into Near Atomic Resolution Electron Cryo-Microscopy Density MapsFrank DiMaio and Wah Chiu11. Refinement of Atomic Structures Against CryoEM MapsGarib N. Murshudov12. Cryo-EM Structure Determination Using Segmented Helical Image ReconstructionSimon A. Fromm and Carsten Sachse13. Cryo-Electron Tomography and Subtomogram AveragingWilliam Wan and John A.G. Briggs