Zodwa Dlamini is a Professor of Molecular Oncology and the founding Director and the Executive Head of the Pan African Cancer Research Institute (PACRI) in South Africa. She is the Director of South African Medical Research Council (SAMRC) Precision Oncology Research Unit (PORU). She is the DSI/NRF SARChI Chair in Precision Oncology and Cancer Prevention (POCP). She is a member of the American Association for Cancer Research (AACR) Advisory Group on Sub-Saharan Africa. She is a member of the AACR Pathology Resources in Africa Advisory Group. Professor Dlamini is a member of the African Organisation for Research and Training in Cancer (AORTIC) Research Committee Scientific Advisory Board. She is an elected member of the Academy of Science of South Africa. Professor Dlamini is an overseas Fellow of the Royal Society of Medicine (London). She is the Associate Editor for Frontiers in Oncology: Cancer Genetics Section

• I: Foundations of exposomics and cancer disparitiesIntroduction: The exposome framework and its relevance to cancer disparitiesEnvironmental exposures and cancer risk: An exposomics perspective in low- and middle-income countriesInfectious agents, HIV, and carcinogenic risks of cancer in low- and middle-income countriesSocioeconomic inequities and the exposome: A double burden in low- and middle-income countriesII: Mechanisms and intersections of the exposomeNeglected tropical diseases, coinfections, and the exposome: The overlapping burden in low- and middle-income countriesClimate change, the exposome, and cancer disparities in low- and middle-income countriesCulture, society, and the exposome: Understanding cancer risk in low- and middle-income countriesGene–environment interactions: The exposome and cancer susceptibilityThe microbiome and the exposome: Implications for cancer riskIII: Exposome-informed strategies for cancer prevention and equityCancer prevention in low- and middle-income countries: Targeting environmental and infectious exposuresStrengthening healthcare systems through exposomicsPolicy reform and environmental justice: Bridging gaps in cancer preventionIV: Innovations and global collaboration in exposomicsEmerging technologies in exposomics: Advancing cancer diagnosis and treatmentArtificial intelligence, big data, and the exposome: Transforming cancer risk assessmentGlobal collaboration in exposomics: A multistakeholder approach to reducing cancer disparitiesThe future of exposomics: Pathways to address cancer disparities in low- and middle-income countries