The Dual Role of Inflammation in Cancer Genesis and Therapy

Prof. Surajit Pathak, PhD, is currently working as a professor at Chettinad Academy of Research and Education (CARE), Chennai, India (from 2015 to date). He is currently serving as a principal research scientist (2022 June–Dec 2022) at Linkoping University, Linkoping, Sweden. He received his PhD degree from India in 2007 and completed his postdoctoral training (2007–15) from the University of Alabama, United States, the University of Padova, Italy, and the University of Linkoping, Sweden. His current research focuses on “Biomarker discoveries for early detection of colorectal cancer.” He has published more than 100 research articles in peer-reviewed international journals of repute with 2233 citations and 27 H-index. Dr. Pathak has edited Elsevier book “Stem Cells and Aging” in 2021. He is the member of various professional research bodies of India, including the Indian Association of Cancer Research and the Indian Science Congress. Dr. Antara Banerjee, PhD, is presently working as an associate professor at CARE, Chennai from 2016 to date. After completing her PhD in 2008 from India, Dr. Banerjee pursued her postdoctoral work at the University of Padova, Italy and Linkoping University, Sweden (2009–15). She has published over 95 peer-reviewed research articles in international and national journals with citation index-1408 and H-index 19. The Banerjee’s lab at Chettinad Hospital and Research Institute is now focused on understanding the role of mesenchymal stem cells niche in tissue regeneration and exploring signaling pathways in governing stem cell fate. She is the editor of Elsevier book “Stem Cells and Aging” in 2021. She is the member of various professional research bodies, including the Indian Association of Cancer Research and the Indian Science Congress.

• 1. Introduction to Inflammation and Cancer2. Chronic Inflammation and Cancer: Epidemiological Evidence3. Role of Inflammatory Cells in Cancer Development4. The Tumor Microenvironment and Inflammation5. Cytokines and Chemokines in Tumorigenesis and Their Pro-tumorigenic and Anti-tumorigenic Roles in Cancer Development6. The Role of Oxidative Stress in Inflammation-Mediated Cancer Progression Inflammation and Metastasis7. Genetic and Epigenetic Changes Driven by Inflammation8. Epigenetic Signaling: Regulation of Inflammation in Cancer9. Inflammation and Tumor Progression: Signaling Pathways10. Biomarkers and Signaling Pathways of Inflammation-Mediated Cancer Development: Promising Targets to Limit11. Metastatic Potential and Stemness12. Anti-inflammatory Agents in Cancer Prevention and Therapy13. Tumor-Infiltrating Inflammatory Cells as Possible Therapeutic Targets14. The Inflammatory Chemokines and in Malignancy: Leukocyte Migration and Beyond15. Inflammation and Beyond: Complex Roles for TGF-β in the Tumor Microenvironment16. Microenvironmental Mediators as Therapeutic Targets in Malignancy17. Role of Macrophages in Regulating Tumor Angiogenesis: Implications for Cancer Therapy18.Immune Forces Impacting DNA-Based Cancer Immunotherapeutic Strategy19. Immunotherapy and Inflammation20.Case Studies: Inflammation-targeted Cancer Therapies21. Microbiota, Inflammation and Colorectal Cancer22. Genomics and Microbiome and Their Immunotherapy Implications in Cancer23. Modulation of Tumor Immunogenicity24. Biomarkers Associated with Immunotherapeutic Response in Cancer25. Endoscopy and AI in the Diagnosis and Early Detection of Dysplastic Lesions26. Chemopreventive Strategies for Inflammation-Related Carcinogenesis: Current Status and Future Direction27.Combinational Immunotherapy Against Cancer28. Policy Recommendations Regarding Immunotherapy and Other Cancer Therapy