Strategic Disconnections in Retrosynthetic Analysis from Pattern Recognition

Strategic Disconnections in Retrosynthetic Analysis from Pattern Recognition: An Applied Approach provides an exhaustive introduction to retrosynthetic analysis, based upon a strategic disconnection approach. It presents a sequence of prioritized disconnections of general structures, each characterized by either a specific functionalization pattern (such as 1,4-dicarbonyl compounds), or a structural motif like the presence of stereogenic centers, bicyclic frameworks, etc. The book provides numerous examples which follow each strategic disconnection of functional or structural motifs. The examples, coming from a careful selection of literature, are organized in the following hierarchical order: i) functional or structural pattern, ii) selected disconnection, iii) polar, radical, or concerted reaction pathway. Unravelling the chemistry behind each example offers excellent training for developing 3D visualization skills, refining critical reasoning in proposing alternative approaches to the synthetic choices found in the literature, and cultivating one's own expertise. In addition to providing an overview through the analysis of various advancements made in organic synthesis over the last 50 years, each strategic disconnection is illustrated with several cases of varying complexity sourced from curated literature. Whilst numerous examples are provided, it is not necessary to examine them all; just a few can be sufficient at first glance to understand a synthetic strategy. Readers can then focus on the most interesting ones from their perspectives or those most akin to their own problems in their lab work. Each case comes with its original reference, enabling readers interested in delving into specific examples to easily find primary information. Strategic Disconnections in Retrosynthetic Analysis from Pattern Recognition: An Applied Approach is written primarily for graduate and postdoc students levels studying organic chemistry and organic synthesis, as well as researchers in industry involved in synthetic chemistry. The general disconnection schemes may also be useful to advanced undergraduate students with a solid foundation in general organic chemistry.