Strategic Disconnections in Retrosynthetic Analysis from Pattern Recognition

Claudio Trombini was appointed a full professor at the University of Bologna in 1994; he currently serves as an Alma Mater Adjunct Professor at the University of Bologna, Italy and is a faculty member of the Erasmus Mundus MSc program in Chemical Innovation and Regulation. He is a fellow of the Academy of Sciences of the Institute of Bologna. He taught Organic Synthesis at the same University from 1979 to 2020, without interruption. His scientific work has received awards from the Italian Chemical Society, including the Pino Medal (2013), and the GICO Senior Prize on organometallic chemistry (2012). He served on the Scientific Committees of the “A. Corbella Summer School on Organic Synthesis” (1996-1998), and the prestigious “Ischia Advanced School of Organic Chemistry” (2009-2018). Among various meetings, workshops, etc., he chaired the “III Italian-German Symposium on Organic Chemistry” in Ravenna in 2001”, the workshop “Perspective and Future Research in Malaria in 2015, and the “XXXVI National Meeting of the Division of Organic Chemistry of the Italian Chemical Society” in 2015.In the last 15 years, he has been member of the International Advisory Board of CHEMCATCHEM, member of the management committee of COST Action CM905-Organocatalysis (ORCA), coordinator of a "great relevance bilateral project" with India and funded by the Italian Foreign Office entitled: Design and Synthesis of new antimalarial molecules. From 2010 he has been visiting professor at the Universities of Pune (India), Algarve (P), Freiburg (CH), and Barcelona (E).His primary scientific interests are centred around methodology-oriented organic synthesis, exploiting organometallic catalysis and organocatalysis to develop new stereoselective transformations. He was actively engaged in function-oriented synthesis, wherein he designed and synthesized new biologically active molecules against the parasites causing malaria and Leishmaniasis. He has also developed new sensors for metals in environmental or biological contexts. Notable examples include studies of mercury speciation in environmental and biological samples, the synthesis of fluorescent ligands for detecting magnesium in cell compartments, and the development of thermochemiluminescent compounds that can be employed as nanoprobes in biosensors and binding bioassays.

• 1. Chemical synthesis as design and construction of molecular architectures: A brief history.2. Organic Synthesis: Basic concepts, definitions, and classification of synthetic steps3. Retrosynthetic Analysis, Glossary, and Operating Instructions directed to the synthesis of alkanes and of ether-type linkages4. One-Group Disconnections: Target molecules containing one carbon-heteroatom bond5. One-group disconnections: Target molecules containing one carbon-carbon multiple bond6. Two-group disconnections: 1,3-Bifunctional compounds containing two carbon-heteroatom bonds (diones, aldols, etc.). FS = 37. Two-group disconnections: Bifunctional compounds containing two carbon-heteroatom bonds (diones, ketols, etc.) with FS = 2, 4, and 58. Two-group disconnections: Bifunctional compounds containing two carbon-carbon double or triple bonds (dienes, diynes, enynes)9. Two-group disconnections: Target molecules containing one carbon-heteratom bond and one carbon-carbon multiple bond10. Topology-guided retrosynthetic analysis11. Ring-guided retrosynthetic analysis of cyclic compounds12. Chirality-guided retrosynthetic analysis13. One-pot multistep reactions14. Organic Synthesis in the 21st Century: The new environment in which organic synthesis is expanding its reach