This thesis describes the inception, design, and implementation of stereoselective desymmetrization reactions in the total synthesis of the natural products pactamycin and paspaline.
Asymmetric Synthesis Of The Aminocyclitol Pactamycin, A Universal Translocation Inhibitor.- Preparation And Biological Evaluation Of Synthetic and Polymer-Encapsulated Congeners of the Antitumor Agent Pactamycin: Insight Into Functional Group Effects and Biological Activity.- Inception and Development of a Global and Local Desymmetrization Approach to the Synthesis of Steroidal Alkaloids: Stereocontrolled Total Synthesis of Paspaline.