Sphingolipid Biology

Inbunden, Engelska, 2006

Av Y. Hirabayashi, Y. Igarashi, A.H. Jr. Merrill, Yoshio Hiarbayashi, Yasuyuki Igarashi, A H Jr Merrill

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Many complex sphingolipids as well as simpler sphingoid bases and derivatives are highly bioactive as extra- and intracellular regulators of growth, differentiation, migration, survival, senescence, and numerous cellular responses to stress.

Produktinformation

Utgivningsdatum2006-07-19
Mått155 x 235 x 32 mm
Vikt1 015 g
FormatInbunden
SpråkEngelska
Antal sidor531
Upplaga2006
FörlagSpringer Verlag, Japan
ISBN9784431341987

Tillhör följande kategorier

Cellbiologi inom Naturvetenskap och teknik
Biokemi inom Naturvetenskap och teknik

Overview.- Sphingolipids Synthesis, Transport and Cellular Signaling.- Biosynthesis, Transport of Sphingolipids.- Serine Palmitoyltransferase.- Ceramide Synthase.- Dihydroceramide: Sphinganine ?4-Desaturase and C4-Hydroxylase.- Metabolizing Enzymes Such As Sphingomyelin Synthase Induce Cell Death by Increasing Ceramide Content.- Glucosylceramide and Galactosylceramide Synthase.- Synthesis, Metabolism, and Trans-Bilayer Movement of Long-Chain Base.- Molecular Mechanism of Ceramide Trafficking from the Endoplasmic Reticulum to the Golgi Apparatus in Mammalian Cells.- Sphingolipid Trafficking.- Current Perspectives on Saccharomyces cerevisiae Sphingolipids.- Generation and Degradation of Sphingolipid Signaling Molecules.- Generation of Signaling Molecules by De Novo Sphingolipid Synthesis.- Overview of Acid and Neutral Sphingomyelinases in Cell Signaling.- Neutral Ceramidase as an Integral Modulator for the Generation of S1P and S1P-Mediated Signaling.- Activation of Sphingosine Kinase 1.- Ceramide 1-Phosphate.- Sphingosine-1-Phosphate Lyase.- Membrane Domain and Biological Function.- Close Interrelationship of Sphingomyelinase and Caveolin in Triton X-100-lnsoluble Membrane Microdomains.- Roles of Membrane Domains in the Signaling Pathway for B Cell Survival.- The Role of Lipid Rafts in Axon Growth and Guidance.- Sphingolipids and Multidrug Resistance of Cancer Cells.- Membrane Lipid Domain and Human Pathobiology.- A New Pathological Feature of Insulin Resistance and Type 2 Diabetes: Involvement of Ganglioside GM3 and Membrane Microdomains.- Neuronal Cell Death in Glycosphingolipidoses.- Endocytic Trafficking of Glycosphingolipids in Sphingolipidoses.- Ganglioside and Alzheimer’s Disease.- Modulation of Proteolytic Processing by Glycosphingolipids Generates Amyloid?-Peptide.- Hereditary Sensory Neuropathy.- Ceramide, Ceramide Kinase and Vision Defects: A BLIND Spot for LIPIDS.- Fumonisin Inhibition of Ceramide Synthase: A Possible Risk Factor for Human Neural Tube Defects.- Sphingolipids and Cancer.- S1P Signaling and SIPR.- Sphingosine-1-Phosphate and the Regulation of Immune Cell Trafficking.- Sphingolipids and Lung Vascular Barrier Regulation.- Signaling Mechanisms for Positive and Negative Regulation of Cell Motility by Sphingosine-1-Phosphate Receptors.- Sphingosine 1-Phosphate-Related Metabolism in the Blood Vessel.- Advanced Technology in Sphingolipid Biology.- Conventional/Conditional Knockout Mice.- Biosynthesis and Function of Drosophila Glycosphingolipids.- Characterization of Genes Conferring Resistance Against ISP-1/Myriocin-Induced Sphingolipid Depletion in Yeast.- Lysenin: A New Probe for Sphingomyelin.- Structural Biology of Sphingolipid Synthesis.- A Computer Visualization Model for the De Novo Sphingolipid Biosynthetic Pathway.