Del 2 i serien Wiley Series on Solid-Phase Organic Syntheses

Solid-Phase Organic Syntheses, Volume 2

Solid-Phase Palladium Chemistry

Inbunden, Engelska, 2012

2 499 kr

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Integrates solid-phase organic synthesis with palladium chemistryThe Wiley Series on Solid-Phase Organic Syntheses keeps researchers current with major accomplishments in solid-phase organic synthesis, providing full experimental details. Following the validated, tested, and proven experimental procedures, readers can easily perform a broad range of complex syntheses needed for their own experiments and industrial applications. The series is conveniently organized into themed volumes according to the specific type of synthesis.This second volume in the series focuses on palladium chemistry in solid-phase synthesis, exploring palladium catalysts and reactions, procedures for preparation and utilization, ligands, and linker reactions. The first part of the volume offers a comprehensive overview of the field. Next, the chapters are organized into three parts: Part Two: Palladium-Mediated Solid-Phase Organic SynthesesPart Three: Immobilized Catalysts and LigandsPart Four: Palladium-Mediated Multifunctional CleavageEach chapter is written by one or more leading international experts in palladium chemistry. Their contributions reflect a thorough examination and review of the current literature as well as their own first-hand laboratory experience. References at the end of each chapter serve as a gateway to the field's literature.The introduction of palladium-mediated, cross-coupling reactions more than thirty years ago revolutionized the science of carbon-carbon bond formation. It has now become a cornerstone of today's synthetic organic chemistry laboratory. With this volume, researchers in organic and medicinal chemistry have access to a single resource that explains the fundamentals of palladium chemistry in solid-phase synthesis and sets forth clear, step-by-step instructions for conducting their own syntheses.

Produktinformation

Utgivningsdatum2012-09-04
Mått160 x 236 x 15 mm
Vikt408 g
FormatInbunden
SpråkEngelska
SerieWiley Series on Solid-Phase Organic Syntheses
Antal sidor184
FörlagJohn Wiley & Sons Inc
ISBN9780470566657

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Contributors ixPreface xiiiAbbreviations xvPART I INTRODUCTION 11. An Introduction to Solid-Phase Palladium Chemistry 3Carmen GilPART II PALLADIUM-MEDIATED SPOS 232. Pd-Catalyzed Solid-Phase Decoration of the 2(1H)-Pyrazinone Scaffold 25Vaibhav P. Mehta and Erik V. Van der Eycken3. One-Step Palladium- and Phenylsilane-Activated Amidation of Solid-Supported Ally Esters 35Zheming Ruan, Katy Van Kirk, Christopher B. Cooper, R. Michael Lawrence, and Michael Poss4. Solid-Phase Reactions of Polymer-Bound Arenesulfonates with Aryl Grignard Reagents 41Kwangyong Park and Chul-Hee Cho5. Fluorous Synthesis of 3-Aminoimidazo[1,2-a]-Pyridine/Pyrazine Library 51Wei Zhang and Yimin Lu6. Resin-to-Resin Transfer Reactions (RRTR) via Sonogashira Coupling 59Judit Tulla-Puche, Rita S. Majerle, Fernando Albericio, and George BaranyPART III IMMOBILIZED CATALYSTS AND LIGANDS 677. Polymer-supported Palladium Catalysts for Suzuki and Heck Reactions 69Peter Styring8. Solid-Phase Catalytic Activity of a Polymer-Supported Palladium Complex 79Maria M. Dell’Anna, Piero Mastrorilli, and Cosimo F. Nobile9. Polyaniline-immobilized Palladium for Suzuki-Miyaura Coupling Reaction in Water 87Moumita Roy, Pravin R. Likhar, and M. Lakshmi Kantam10. Synthesis of Polymer-Supported Aryldicyclohexylphosphine for an Efficient Recycling in Suzuki-Miyaura Reactions 91Katarzyna Glegola and Eric Framery11. C–C or C–N Reactions Catalyzed by Diadamanthylphosphine Palladium-Based Catalyst Supported on Dab-Dendrimers 97Karine Heuzé, Agnés Fougeret, Julietta Lemo, and Daniel Rosario-AmorinPART IV PALLADIUM-MEDIATED MULTIFUNCTIONAL CLEAVAGE 10512. Solid-Phase Reactions of Resin-Supported Boronic Acids 107François Carreaux, Bertrand Carboni, Herve Deleuze, and Christelle Pourbaix-L’Ebraly13. A Simple Diversity Linker Strategy Using Immobilized Enol Phosphonates as Electrophiles for Suzuki-Miyaura Reactions 119Tom M. Woods14. Heck Cleavage of Resin-bound Triazenes 129Sylvia Vanderheiden, Nicole Jung, and Stefan Bräse15. Pd-Mediated Cleavage from Tetrafluoroarylsulfonate Linker Units 139Andrew N. Cammidge and Zainab Ngaini16. Palladium-Catalyzed Solid-Phase Synthesis of Allylic Amines 145Richard C. D. Brown and Martin L. Fisher17. Palladium-Catalyzed Solid-Phase Synthesis of 4-Methylene Pyrrolidines 157Lynda J. Brown, Richard C. D. Brown, and Martin L. FisherIndex 167

“Overall, though, the adoption of an Organic Synthesesstyle is an excellent idea and works very well. Along with other related volumes, this collection serves to demystify polymer-supported methods for palladium-catalysed reactions and provides a very useful collection of clear methods. It will certainly be of interest and use to those new to the fi eld.” (Platinum Metals Review, 1 July 2013)