Handbook of Radiopharmaceuticals

Methodology and Applications

Inbunden, Engelska, 2021

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The thoroughly updated new edition of the authoritative reference in Radiopharmaceutical SciencesThe second edition of Handbook of Radiopharmaceuticals is a comprehensive review of the field, presenting up-to-date coverage of central topics such as radionuclide production, synthetic methodology, radiopharmaceutical development and regulations, and a wide range of practical applications. A valuable reference work for those new to the Radiopharmaceutical Sciences and experienced professionals alike, this volume explores the latest concepts and issues involving both targeted diagnostic and therapeutic radiopharmaceuticals. Contributions from a team of experts from across sub-disciplines provide readers with an immersive examination of radiochemistry, nuclear medicine, molecular imaging, and more.Since the first edition of the Handbook was published, Nuclear Medicine and Radiopharmaceutical Sciences have undergone major changes. New radiopharmaceuticals for diagnosis and therapy have been approved by the FDA, the number of clinical PET and SPECT scans have increased significantly, and advances in Artificial Intelligence have dramatically improved research techniques. This fully revised edition reflects the current state of the field and features substantially updated and expanded content. New chapters cover topics including current Good Manufacturing Practice (cGMP), regulatory oversight, novel approaches to quality control—ensuring that readers are informed of the exciting developments of recent years. This important resource: Features extensive new and revised content throughoutCovers key areas of application for diagnosis and therapy in oncology, neurology, and cardiologyEmphasizes the multidisciplinary nature of Radiopharmaceutical SciencesDiscusses how drug companies are using modern radiopharmaceutical imaging techniques to support drug discoveryExamines current and emerging applications of Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT)Edited by recognized experts in radiochemistry and PET imaging, Handbook of Radiopharmaceuticals: Radiochemistry and Applications, 2nd Edition is an indispensable reference for post-doctoral fellows, research scientists, and professionals in the pharmaceutical industry, and for academics, graduate students, and newcomers in the field of radiopharmaceuticals.

Produktinformation

Utgivningsdatum2021-02-11
Mått211 x 252 x 41 mm
Vikt1 996 g
FormatInbunden
SpråkEngelska
Antal sidor768
Upplaga2
FörlagJohn Wiley & Sons Inc
ISBN9781119500544

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Edited by Michael R. Kilbourn, PhD, is Professor Emeritus, Radiology, at the University of Michigan. He retired after 25 years of directing and expanding the University's PET Cyclotron and Radiochemistry program. Professor Kilbourn is the author of over 200 peer-reviewed scientific papers and 31 book chapters, and is the 2009 recipient of the Paul C. Aebersold Award for Outstanding Achievements in Basic Science Applied to Nuclear Medicine. Peter J. H. Scott, PhD, is Associate Professor, Radiology, and Director of the PET Center at the University of Michigan. His research focuses on developing new methods for radiolabeling bioactive molecules and the design and synthesis of new radiotracers for PET imaging. Professor Scott has published over 100 papers, 170 abstracts, and 30 book chapters, edited 4 books, and is listed as an inventor on multiple patents. In 2019 he received a Distinguished Investigator Award from the Academy for Radiology & Biomedical Imaging Research.

ForewordPrefaceList of ContributorsAbout the EditorsAbbreviationsPART I: INTRODUCTION TO RADIOPHARMACEUTICALS1. Targeted Diagnostic Radiopharmaceuticals: Design Options for Small Molecule RadiotracersMichael R. Kilbourn2. Concepts and Issues for Therapeutic RadiopharmaceuticalsAlexandra R. Sowa Dumond and Peter J. H. ScottPART II: PRODUCTION OF RADIONUCLIDES3. Production of Short Half-life PET RadionuclidesMichael R. Kilbourn, Melissa E. Rodnick and Mara Clark4. Production of Radionuclides used in SPECTSalma Jivan and Thomas J. Ruth5. Production of Therapeutic RadionuclidesC. Shaun Loveless and Suzanne E. LapiPART III: SYNTHETIC METHODS FOR RADIOPHARMACEUTICALS6. Synthesis of 13N- and 15O-labeled RadiopharmaceuticalsKrishna R. Pulagam, Vanessa Gómez-Vallejo, Fernando López-Gallego, Luka Rejc and Jordi Llop7. Radiochemistry with Carbon-11Stephen Thompson, Steven Kealey, Selena M. Sephton and Franklin I. Aigbirhio8. Fluorine-18 RadiochemistryAllen F. Brooks, Katarina J. Makaravage, Jay Wright, Melanie S. Sanford and Peter J. H. Scott9. Synthesis of 68Ga-labeled RadiopharmaceuticalsBenjamin P. Burke and Stephen J. Archibald 10. Cu-Mediated Radiohalogenation of OrganoboranesSean W. Reilly and Robert H. Mach11. The radiochemistry of zirconiumJason P. Holland12. 99mTc Radiopharmaceutical ChemistryDionysia PapagiannopoulouPART IV: PRACTICAL ASPECTS OF RADIOPHARMACEUTICAL PRODUCTION AND USE13. Automated Synthesis Modules for PET RadiochemistryLaura Bruton and Peter J. H. Scott14. Automation of PET Radiopharmaceutical Quality ControlArkadij Elizarov15. Moving PET Drugs from the Lab to the Patient in USADavid W. Dick16. Moving from the Lab to the Patient in AsiaDae Yoon Chi17. Moving a radiotracer form bench to bedside in EuropeKoen Vermeulen, Alfons Verbruggen, Guy Bormans and Frederik CleerenPART V: MAJOR APPLICATIONS OF RADIOPHARMACEUTICALS18. Radiopharmaceuticals in OncologyJeroen A.C.M. Goos, Outi Keinänen, Brian M. Zeglis and Jason S. Lewis19. Neurological applications of RadiopharmaceuticalsMehdi Djekidel and Nicolaas I. Bohnen20. Cardiac Applications of RadiopharmaceuticalsJohn P. Bois and Robert J. Gropler21. Radiopharmaceuticals in Pediatric Nuclear MedicineScott E. Snyder, Elizabeth R. Butch and Barry L. Shulkin22. PET Imaging in Drug Discovery and DevelopmentDavid J. DonnellyINDEX