Role of Lipid Excipients in Modifying Oral and Parenteral Drug Delivery

Basic Principles and Biological Examples

Inbunden, Engelska, 2006

AvKishor M. Wasan,British Columbia) Wasan, Kishor M. (University of British Columbia, Vancouver

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This comprehensive resource covers the fundamentals, formulation, and biopharmaceutical issues of lipid-based drug delivery. It presents the principles of lipid absorption and covers formulation issues, such as dissolution testing and stability testing, and physiological and biopharmaceutical issues, including the role of specific enzymes, the evaluation of transport systems in the body, and the mechanisms governing the transport of water-insoluble drugs.

Produktinformation

Utgivningsdatum2006-11-24
Mått161 x 243 x 19 mm
Vikt494 g
FormatInbunden
SpråkEngelska
Antal sidor216
FörlagJohn Wiley & Sons Inc
ISBN9780471739524

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Farmakologi inom Medicin

KISHOR M. WASAN, PhD, is a Professor and Distinguished University Scholar at The University of British Columbia Faculty of Pharmaceutical Sciences. He is the Chairman of the AAPS Focus Group in Parenteral Lipid-Based Drug Delivery Systems. His research has earned him over $10 million in grants and funding, and he has written over 290 peer-reviewed publications and abstracts. In addition, he holds five patents and has worked as a consultant and publications reviewer. Dr. Wasan is a Fellow of the American Association of Pharmaceutical Sciences (AAPS) and a member of the Canadian Society of Pharmaceutical Sciences, American Pharmacists Association (APhA), and Pharmaceutics and Drug Delivery Awards Committee, among others.

Preface. Contributors. Chapter 1. Interaction of Drug Transporters with Excipients (K. Sandy Pang, Lichuan Liu, and Huadong Sun). Chapter 2. Formulation Issues around Lipid-Based Oral and Parenteral Delivery Systems (Seong Hoon Jeong, Jae Hyung Park and Kinam Park). Chapter 3. Lipid-Based Parenteral Drug Delivery Systems: Biological Implications (Vladimir P. Torchilin). Chapter 4. Principles in the Development of Intravenous Lipid Emulsions (Joanna Rossi and Jean-Christophe Leroux). Chapter 5. Protein adsorption patterns on parenteral lipid formulations-key factor determining the in vivo fate (Rainer H. Muller and Torsten M. Goppert). Chapter 6. Nanoparticle targeting for drug delivery across the blood brain barrier (James Egbert, Werner Geldenhuys, Fancy Thomas, Paul R. Lockman, Russell J. Mumper and David D. Allen). Chapter 7. Lipid-Coated Perfluorocarbon Nanostructures as Parenteral Therapeutic Agents (Evan C. Unger, Terry O. Matsunaga and Reena Zutshi). Index.