RNA Interference and Cancer Therapy

Methods and Protocols

Häftad, Engelska, 2020

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This comprehensive volume collects a repertoire of techniques for the adoption and exploitation of RNA interference (RNAi) as a fertile strategy to develop the bio-drugs of future in the vital field of cancer research.

Produktinformation

Utgivningsdatum2020-08-14
Mått178 x 254 x 24 mm
Vikt808 g
FormatHäftad
SpråkEngelska
SerieMethods in Molecular Biology
Antal sidor416
FörlagHumana Press Inc.
ISBN9781493992225

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siRNA Library Screening to Identify Complementary Therapeutic Pairs in Triple Negative Breast Cancer Cells.- In Vitro Evaluation of Candidate Gene Targets for Cancer Therapy.- siRNA-Based Drug Targeting Human Bcl-xL against Cancers.- Relative Quantification of siRNA Strand Loading into Ago2 for Design of Highly-Active siRNAs.- VEGFA Gene Silencing in CXCR4-Expressing Cells via siRNA Delivery by Means of Targeted Peptide Carrier.- Design Strategy to Access siRNA-Encapsulating DNA “Nanosuitcases” that Can Conditionally Release their Cargo.- Combinatorial siRNA Polyplexes for Receptor Targeting.- Synthesis of Doxorubicin and miRNA Stimuli-Sensitive Conjugates for Combination Therapy.- Minicell-Based Targeted Delivery of shRNA to Cancer Cells: An Experimental Protocol.- Targeted Delivery of miRNA Antagonists to Myeloid Cells In Vitro and In Vivo.- Systemic Modulation of Lymphocyte Subsets Using siRNAs Delivered via Targeted Lipid Nanoparticles.- Targeting Cancer with Peptide RNAi Nanoplexes.- Preparation of a Carrier to Achieve In Vivo Delivery of siRNA: The Example of Chitosan-Coated Poly(isobutylcyanoacrylate) Nanoparticles.- Monoclonal Antibody-Conjugated Dendritic Nanostructures for siRNA Delivery.- Synthesis of Gold Nanoparticles for Gene Silencing.- Design of Eco-Friendly Gold Nanoparticles for Cancer Treatment.- 64Cu-Labeled Aptamers for Tumor-Targeted Radionuclide Delivery.- Silencing PRDM14 via Oligonucleotide Therapeutics Suppresses Tumorigenicity and Metastasis of Breast Cancer.- Bio-Drug Suppresses Breast and Colorectal Cancer in Murine Models.- Combinatorial Nanoparticle Delivery of siRNA and Antineoplastics for Lung Cancer Treatment.- Bioconjugated Gold Nanoparticles Enhance siRNA Delivery in Prostate Cancer Cells.- Vaginal Suppositories with siRNA and Paclitaxel-Incorporated Solid Lipid Nanoparticles for Cervical Cancer: Preparation and In Vitro Evaluation.- The Use of Star Polymer Nanoparticles for the Delivery of siRNA to Mouse Orthotopic Pancreatic Tumor Models.- Microfluidic Assembly of siRNA-Loaded Micelleplexes for Tumor Targeting in an Orthotopic Model of Ovarian Cancer.- Synthesis, Physico-Chemical, and Biological Evaluation of Spherical Nucleic Acids for RNAi-Based Therapy in Glioblastoma.- Folate-Decorated Polyamidoamine Dendrimer Nanoparticles for Head and Neck Cancer Gene Therapy.