Protein-Protein Interactions in Human Disease, Part A

Rossen Donev received his PhD degree in 1999 from the Institute of Molecular Biology, Bulgarian Academy of Sciences. He did postdoctoral training at Imperial Cancer Research Fund, UK (renamed after the merger with Cancer Research Campaign to Cancer Research UK, London Research Institute) and Cardiff University. In 2007 he was awarded a New Investigator Grant Award from the Medical Research Council (UK) to establish himself as an independent Principle Investigator. In 2010 Dr. Donev was appointed Senior Lecturer at Swansea University. In 2016 Dr. Donev joined MicroPharm Ltd (UK) where currently he is Head of Research. He has published more than 60 research papers, chaired scientific meetings and given invited plenary talks. Rossen Donev has consulted on projects related to development of treatments for neurodevelopmental disorders and cancer therapies. He serves as Editor-in-Chief of the Advances in Protein Chemistry and Structural Biology and on editorial board of several other journals. His research interests include signaling pathways involved in neuropsychiatric disorders and tumor escape from the immune system, and development of therapeutic strategies for their treatment. More recently he has focused on development of immunotherapeutics for non-systemic applications.

• 1. Analysis of protein interactions by surface plasmon resonance Dennis G. Drescher2. Using TR-FRET to investigate protein-protein interactions: a case study of PXR-coregulator interaction Taosheng Chen3. Protein-Protein Interaction Modulators for Epigenetic TherapiesJose L. Medina-Franco4. Intrinsic disorder, protein-protein interactions and disease Vladimir N. Uversky5. Targeting protein-protein interactions in the ubiquitin-proteasome pathwayMaria Gaczynska6. Protein-protein networks involved in MODY familyGeorge Priya Doss P. C7. Defining HIV-1 replication mechanisms by analyzing virus-host protein interactions Manuel Llano8. Proteomics of occupational diseasesNicola Luigi Bragazzi9. Proteomics of sport-related injuriesNicola Luigi Bragazzi10. Structural prediction of protein-protein interactions by docking: application to biomedical problemsJuan Fernandez-Recio11. Computational methods in predicting the impact of SNPs in Protein-protein networkGeorge Priya Doss P. C

"...all of the authors of the book succeeded in showing highly exciting and unique opportunities for unraveling the functional behavior of complex protein-protein interactions in human diseases. ...The volume shows the enormous complexity in the field of PPI in human diseases. It is a collection of topics without pretending in-depth analysis of a single subject. Each theme and chapter stands on its own, but all have protein-protein interactions in common." --The Quarterly Review of Biology