Joaquim Ros is Professor at the University of Lleida. From 1995 his research interest has been focused on studying the effect of oxidative stress on proteins in several models (from bacteria to humans) and how this damage affects protein function. He is the head of the Dept. of Basic Medical Sciences, Faculty of Medicine, University of Lleida.

• List of Contributors xiiPreface xvi1 Reactive Oxygen Species Signaling from the Perspective of the Stem Cell 1Saghi Ghaffari and Raymond Liang1.1 Introduction 11.2 ROS Regulation 21.3 ROS Signaling 31.4 ROS and Stem Cells 51.5 ROS, Metabolism, and Epigenetic Influence 91.6 Stem Cells and Mitochondria 91.7 ROS and Stem Cell Aging 122 Analysis of Protein Carbonylation 24Ashraf G. Madian, Fred E. Regnier, and Ao Zeng2.1 Introduction 242.2 In Vivo Carbonylation Reactions 272.3 Analytical Derivatization of Carbonylated Groups 342.4 Selective Purification and/or Detection of Carbonylated Proteins and Peptides 362.5 Oxidative Stress]Based PTMS Not Involving Carbonylation 383 Diversity of Protein Carbonylation Pathways: Direct Oxidation,Glycoxidation, and Modifications by Lipid Peroxidation Products 48Maria Fedorova3.1 Introduction 483.2 Pathways of Protein Carbonylation 493.3 Analytical Methods for Detection of Total and Specific Protein Carbonylation 573.4 Protein Susceptibility to Different Carbonylation Pathways and Modifications Cross]Talk 674 Protein Carbonylation by Reactive Lipids 83Koji Uchida4.1 Introduction 834.2 Chemistry of Protein Carbonylation by Reactive Lipid Aldehydes 844.3 Antigenicity of Protein Carbonyls 874.4 Thiolation of Protein Carbonyls 894.5 Reductive Amination]Based Fluorescent Labeling of Protein Carbonyls 915 Mechanism and Functions of Protein Decarbonylation 97Yuichiro J. Suzuki5.1 Protein Carbonylation 975.2 Primary Protein Carbonylation in Cell Signaling 985.3 Discovery and Mechanisms of Protein Decarbonylation 1015.4 Proposed Functions of Protein Decarbonylation in Oxidative Stress and Redox Signaling 1036 Carbonylated Proteins and Their Metabolic Regulation: Overview of Mechanisms, Target Proteins, and Characterization Using Proteomic Methods 110Somaieh Afiuni]Zadeh and Timothy J. Griffin6.1 Metabolic Regulation and Reactive Oxygen Species 1106.2 ROS and Protein Carbonylation 1116.3 Metabolic Control and Characteristics of Carbonylated Proteins 1136.4 Protein Targets of Carbonylation and Implications in Human Health 1146.5 Technologies and Methods for Characterizing Protein Carbonylation 1186.6 Emerging Multifunctional Reagents for Protein Carbonylation Analysis via MS 1196.7 Emerging Methods for Characterizing Carbonylated Protein Networks and Affected Pathways 1237 Oxidative Stress and Protein Carbonylation in Malaria 131Maria Linares, Antonio Puyet, Amalia Diez, and Jose M. Bautista7.1 Introduction 1317.2 Oxidative Stress during Malaria Infection 1327.3 Protein Carbonylation in Plasmodium and Oxidative Targeting of Antimalarials 1377.4 Oxidative Dysfunction in Host Tissues 1437.5 Host Tolerance to Malaria by Modulation of Oxidative Stress Responses 1487.6 Perspectives 1538 Protein Carbonylation in Brains of Subjects with Selected Neurodegenerative Disorders 167Tanea T. Reed and D. Allan Butterfield8.1 Introduction to Protein Carbonylation 1678.2 Relationship between ROS and Oxidative Stress 1698.3 An Overview of Some Neurodegenerative Diseases 1718.4 Role of Protein Carbonylation in Brains of Subjects with AD 1748.5 An Introduction to Tauopathies 1858.6 An Introduction to Amyotrophic Lateral Sclerosis 1869 Cigarette Smoke]Induced Protein Carbonylation: Focus on Recent Human Studies 206Graziano Colombo, Maria Lisa Garavaglia, Aldo Milzani, and Isabella Dalle]Donne9.1 Introduction 2069.2 Protein Carbonylation in Human Smokers 2129.3 Protein Carbonylation in Cultured Human Cell Models of Exposure to CS 2189.4 Limitations and Congruence of In Vivo and In Vitro Human Studies 22810 Chronic Obstructive Pulmonary Disease and Oxidative Damage 241Esther Barreiro10.1 Introduction 24210.2 Protein Oxidation in Tissues 24410.3 Antioxidants in Skeletal Muscle Fibers 24710.4 Implications of Protein Carbonylation in COPD Skeletal Muscle Dysfunction 24910.5 Muscle Protein Carbonylation and Exercise in COPD Patients 25210.6 Protein Carbonylation in Muscles Exposed to Chronic Cigarette Smoke 25310.7 Protein Carbonylation in Cancer Cachexia Models 25510.8 Protein Carbonylation as a Predisposing Mechanism of Lung Cancer in COPD 25711 Protein Carbonylation in Aging and Senescence 272Jeannette Konig, Tobias Jung and Tilman Grune11.1 Introduction 27211.2 Protein Oxidation during Aging 27411.3 Chemistry of Protein Carbonylation and Fate of Carbonylated Proteins 27711.4 Protein Carbonyls in Cellular Aging Models 27911.5 Protein Carbonylation in Aging Organisms 28012 Adipose Carbonylation and Mitochondrial Dysfunction 291Amy K. Hauck, Dalay H. Olson, Joel S. Burrill, and David A. Bernlohr12.1 Introduction 29112.2 Reactive Oxygen Species (ROS) 29212.3 Oxidative Stress and Obesity 29812.4 Detection of Protein Carbonylation 30312.5 Outcomes of Protein Carbonylation 30613 Protein Carbonylation in Plants 321Ian Max Moller, Jesper F. Havelund, and Adelina Rogowska]Wrzesinska13.1 Introduction 32213.2 Turnover of Reactive Oxygen Species in Plants 32313.3 Methods Used in Plants for Quantifying and Identifying Carbonylation Sites 32513.4 Protein Carbonylation in Plants 32613.5 Protein Carbonylation in Plant Mitochondria 32813.6 Protein Carbonylation in Seeds 33314 Specificity of Protein Carbonylation and Its Relevance in Aging 340Elisa Cabiscol, Jordi Tamarit, and Joaquim Ros14.1 Introduction 34014.2 Specificity of Protein Oxidative Damage 34114.3 Protein Carbonylation in Aging 348Index 384

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