Protection Against Ischemia/Reperfusion Damage of the Heart

How to protect against ischemia and reperfusion damage is one of the most urgent problems in medicine. It is known that ischemic damage can be attenuated by improving the oxygen balance of the ischemic heart, but the damage producing mechanism is not yet fully understood. This book provides the latest information on the pathophysiology of ischemia/reperfusion damage and presents new ideas for more effective methods for protection. In the first two sections, the roles of such factors as various ions and phospholipids that modulate ischemia and reperfusion damage are explored, providing a clear and updated explanation of the mechanisms involved. In the third section, the myocardial and vascular remodelling procedure in hearts that have undergone ischemia and reperfusion is explained in terms of signal transduction, enabling a new understanding of the remodelling process. In the final section, a new approach to protection against ischemia and reperfusion damage is presented.