Principles of Nutrigenetics and Nutrigenomics

Raffaele De Caterina is a Professor of Cardiology at the University of Pisa and Director of the University Cardiology Division at Pisa University Hospital, Pisa, Italy. He has been President of the International Society on Nutrigenetics/Nutrigenomics (2009-2013) and vice-President of the European Society of Cardiology (2008-2010). He is Editor-in-Chief of the journal Vascular Pharmacology and author of over 600 peer-reviewed manuscripts. His major research interests include cardiovascular pharmacology, atrial fibrillation, coronary artery disease, and cardiovascular thrombosis, as well as nutrigenetics and nutrigenomics. Prof. J. Alfredo Martínez has been involved in several landmark intervention trials and more than 50 national and international projects. He has supervised more than 70 PhD students and published more than 800 peer-reviewed manuscripts and book chapters in the areas of obesity and personalized nutrition, including precision nutritional omics. His works have been cited more than 26,000 times, and his HFactor is over 64. He has been President of the International Society of Nutrigenetics/Nutrigenomics (2015-2017) and is President of the International Union of Nutritional Sciences (IUNS) for the 2017-2021 period. Prof. Martínez has enjoyed training or invited stays at the University of Nottingham, Berkeley College, MIT, Harvard University, Oxford University, and King’s College London. He has been an advisor for EU Projects or a guest speaker or main keynote lecturer in important forums concerning precision nutrition in obesity and cardiometabolic diseases, including IUNS, ISNN, OMS, FAO, IAEA, NIH, SLAN, and FENS. Dr. Martin Kohlmeier, MD, PhD, is a Professor of Nutrition; Director of the Human Research Core and the Nutrigenetics Laboratory at the UNC Nutrition Research Institute in Kannapolis, NC; Director of Nutrition in Medicine for online nutrition education of medical students and health professionals; visiting fellow of Wolfson College at Cambridge University, UK; founding Editor-in-Chief of BMJ Nutrition, Prevention and Health; and President of the International Society of Nutrigenetics/Nutrigenomics (ISNN). His professional interests include investigating genotype-specific nutrition responses of humans in health and disease, developing decision-support algorithms and tools for precision nutrition, and teaching health care professionals how to use nutrigenetics in practice. His previously authored textbooks in the field include Nutrigenetics (Academic Press, 2013) and Nutrient Metabolism (2nd Edition, Academic Press, 2015).

• Section 1: The biological basis of heritability and diversity1. The nature of traits, genes and variation2. Molecular biology of genetic variants3. Regulation of Gene Expression4. The role of nutrition in DNA replication, DNA damage prevention and DNA repair5. Genotyping and sequencing6. RNA analyses7. Methods in Nutrigenomics for precision nutrition8. Epigenetics: Methodology and tools for nutrition research9. Proteomic analyses10. Metabolomic analyses11. Metagenomics12. A Broader View on Omics and Systems Biology13. Study design in genomic epidemiology14. Epistemology of nutrigenetic knowledgeSection 2: Nutrigenetics15. Nutrigenetics and the early life origins of health and disease: effects of protein restriction16. Perinatal nutrition17. Epigenetics Mechanisms18. Genetics of Chrononutrition19. Newborn screening20. Genomics of Eating Behavior and Appetite Regulation21. Genetics of Body Composition: From Severe Obesity to Extreme Leanness22. Genetic regulation of energy homeostasis: obesity implications23. Genetic variations in the response to weight-loss diets24. Genetic variations in the response to exercise: impact on physical fitness and performance25. Genetic variations impacting the response to defined diets26. Carbohydrates27. Monounsaturated and Saturated Fatty Acids28. Omega-3 and omega-6 fatty acids 29. Blood cholesterol30. Genetic Individuality and Alcoholic Consumption31. Vitamin A and other carotenoids32. Vitamin D33. Vitamin E34. Vitamin K35. Vitamins as Cofactors for Energy Homeostasis: Biotin, Thiamine and Pantothenic Acid36. Vitamin C37. Vitamin B238. Niacin39. Folate, vitamin B6, vitamin B1240. Choline 41. Electrolytes42. Iron43. Trace elements44. Polyphenols and Nutrigenetic/Nutrigenomic Associations with Obesity-Related Metabolic Diseases45. Caffeine46. Phytanic acid47. Cognitive function48. Cardiovascular Disease49. Hemostasis and thrombosis50. Diabetes mellitus51. Bone health52. Nutrients and Genes in the Liver53. Hyperuricemia and gout54. Aging55. Epigenetics in food allergies: the missing piece of the puzzle56. Gut microbiota and their influence on the response to foodsSection 3: Nutrigenomics57. Nutrients and Gene Expression in Development58. Nutrients and gene expression in Obesity59. Nutrients and gene expression in Diabetes60. Gene expression in dyslipidemias 61. Nutrients and gene expression in Inflammation 62. Nutrients and gene expression in Cardiovascular Disease63. Nutrients and Gene Expression in Cancer64. Nutrients and Gene Expression Affecting Bone MetabolismSection 4: Translational nutrigenetics and nutrigenomics65. Nutrigenetics-based intervention studies66. Genome-based nutrition guidance67. Nutrigenomics of food pesticides68. Pharmaconutrigenetics: the impact of genetics on nutrient-drug interactions69. Setting genome-directed guidelines and algorithms70. Direct-to-consumer services 71. Privacy risks and protective measures 72. Ethical considerations in nutrigenetics and nutrigenomics73. Impact of Nutrigenetics and Nutrigenomics on Society