Post-transcriptional Mechanisms in Endocrine Regulation

Inbunden, Engelska, 2016

Av K.M.J. Menon, PhD, Aaron Goldstrohm, PhD, K. M. J. Menon Phd, Aaron Goldstrohm Phd, Menon, Goldstrohm

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This book examines how post-transcriptional mechanisms control endocrine function. This includes newly identified regulatory mechanisms involved in hormone biosynthesis, control of hormone receptors and the outputs of hormone mediated signal transduction. Chapters address endocrine hormones including protein peptide/peptide, steroid, and non-steroidal hormones. The impacts of these mechanisms on disease and health are covered, providing a novel update to the scientific literature. Post-transcriptional regulatory mechanisms play an essential role in controlling dynamic gene expression. The outcome of this regulation includes control of the amount, timing, and location of protein expression. Regulation is mediated by cis-acting RNA sequences and structures and transacting RNA binding proteins and non-coding RNAs, including microRNAs. Recent advances in characterization of these regulatory factors have revealed enormous regulatory potential.

Produktinformation

Utgivningsdatum2016-01-08
Mått155 x 235 x 25 mm
Vikt705 g
FormatInbunden
SpråkEngelska
Antal sidor341
Upplaga16001
FörlagSpringer International Publishing AG
ISBN9783319251226

Tillhör följande kategorier

Medicinsk genetik inom Medicin
Endokrinologi inom Medicin
Fysiologi inom Medicin
Biovetenskap inom Naturvetenskap och teknik

Mechanisms of post-transcriptional gene regulation.- Post-transcriptional regulation of insulin and insulin like growth factor.- Posttranscriptional regulation of cytokine signaling during inflammatory responses.- Regulation of luteinizing hormone Receptor mRNA expression in the ovary.- Post-transcriptional regulation of steroid hormone receptors microRNA regulation of endocrine function in the ovary.- Translational control in the germline.- Post-transcriptional regulation of VEGF-A.- Post-transcriptional regulation of prostaglandin biosynthesis.- Translational and post-translational control of leptin production by fat cells.- Post-transcriptional regulation of parathyroid hormone gene expression in health and disease.- Post-transcriptional and post-translational regulation in steroidogenesis.- Post-transcriptional regulation of glucocorticoid function.- Post-transcriptional regulation by brain-derived neurotrophic factor in the nervous system.