Pharmacology of the WNT Signaling System

Inbunden, Engelska, 2021

2 099 kr

Beställningsvara. Skickas inom 10-15 vardagar

Fri frakt för medlemmar vid köp för minst 249 kr.

This book reflects the state of the art of our understanding of the WNT signaling system, which comprises a network of signaling pathways initiated by the secreted WNT lipoglycoproteins, which are crucial for embryonal development, stem cell regulation, tissue homeostasis and repair.

Produktinformation

Utgivningsdatum2021-10-30
Mått155 x 235 x 28 mm
Vikt889 g
FormatInbunden
SpråkEngelska
SerieHandbook of Experimental Pharmacology
Antal sidor422
FörlagSpringer Nature Switzerland AG
ISBN9783030854980

Tillhör följande kategorier

Onkologi inom Medicin
Biologi inom Naturvetenskap och teknik
Biovetenskap inom Naturvetenskap och teknik
Farmakologi inom Medicin

Pharmacological thinking in WNT signaling.- Controlling WNT Signaling Specificity and implications for targeting WNTs pharmacologically.- WNTs on exosomes.- Strategies to target LRPs in WNT signaling.- Targeting the receptor tyrosine kinase ROR1 by small molecules.- Assessing WNT binding and Frizzled activation employing genetically encoded, biophysical sensors.- Disheveled proteins as crucial mediators of WNT signaling.- Destruction complex and regulation of CTNNB1.- Strategies to therapeutically target WNT/PCP like signaling in disease.- Mining natural compounds to target WNT signaling - from mushrooms to corals.- FZD7 as a therapeutic target in intestinal cancer.- Targeting oncogenic WNT signaling with WNT derived peptides.- Targeting WNT signaling in lung pathology.- The role of WNT signaling in osteoarthritis and the therapeutic potential of its pharmacological targeting.- WNT signaling in Alzheimers disease and other neurodegenerative disorders - opportunities for therapy?.- Targeting WNT signaling as a risk.