Personalized Psychiatry

Prof. Bernhard Baune (PhD, MD, MPH, FRANZCP) is the Director of the University Hospital Department of Psychiatry and Psychotherapy, University of Münster, Germany. He also leads the newly established Laboratory Division of Molecular Neurobiology of Mental Health at the University. Prof. Baune has been the Cato Chair and Head of Department of Psychiatry at the University of Melbourne, Australia prior to being awarded the Director position at the University of Münster. Prof. Baune is a Fellow of the Royal Australian and New Zealand College of Psychiatrist (FRANZCP), he is a Professorial Fellow of the Department of Psychiatry, University of Melbourne and also at the Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Australia.Prof. Baune is known for his extensive research program into depression and cognitive dysfunction, personalised psychiatry, molecular psychiatry, prediction and biomarker research and treatment response research as well as for key research achievements in the field of immune-neurobiology of psychiatric disorders.Prof. Baune’s translational work at the University of Münster is designed to make real-world differences to the lives of people with mental illness by integrating neurobiological and clinical information, by personalising treatments and by targeting the mechanisms of functional recovery.Other related work include the leadership of an international consortium on the genomics of severe depression and response to ECT in affective disorders (GenECT-ic), leading an international study on the genomics of cognitive function in depression and directing the ECNP network on trans- diagnostic pharmacogenomics and transcriptomics in psychiatric disorders.His research is nationally and internationally recognised and he has published more than 500 peer-reviewed articles, reviews and book chapters, and he edited several text books in Psychiatry, and most recently the books “Personalised Psychiatry” (Elsevier), “Inflammation and Immunity of Depression” (Elsevier) and “Cognitive Dimensions of Major Depressive Disorder” (Oxford University Press).

• PrefaceBernhard Theodor Baune1. What is personalized psychiatry and why is it necessary?Bernhard Theodor Baune2. The modeling of trajectories in psychotic illnessScott R. Clark, Klaus Oliver Schubert, and Bernhard T. Baune3. Mood trajectories as a basis for personalized psychiatry in young peopleKlaus Oliver Schubert, Scott R. Clark, Linh K. Van, Jane L. Collinson, and Bernhard T. Baune4. Transdiagnostic early intervention, prevention, and prediction in psychiatryCristina Mei, Barnaby Nelson, Jessica Hartmann, Rachael Spooner, and Patrick D. McGorry5. Early intervention, prevention, and prediction in mood disorders: Tracking multidimensional outcomes in young people presenting for mental health careElizabeth M. Scott, Joanne S. Carpenter, Frank Iorfino, Shane P.M. Cross, Daniel F. Hermens, Django White, Rico S.Z. Lee, Sharon L. Naismith, Adam J. Guastella, Nicholas Glozier, F. Markus Leweke, Dagmar Koethe, Jim Lagopoulos, Jan Scott, Blake A. Hamilton, Jacob J. Crouse, Ashleigh M. Tickell, Alissa Nichles, Natalya Zmicerevska, Lillian J. Gehue, Manreena Kaur, Kate M. Chitty, and Ian B. Hickie6. Consumer participation in personalized psychiatryHarris A. Eyre, Elisabeth R.B. Becker, Marissa S. Blumenthal, Ajeet B. Singh, Cyrus Raji, Arshya Vahabzadeh, Zoe Wainer, and Chad Bousman7. Experimental validation of psychopathology in personalized psychiatryAlfons O. Hamm8. Deep brain stimulation for major depression: A prototype of a personalized treatment in psychiatryThomas E. Schlaepfer and Bettina H. Bewernick9. The Psychiatric Genomics Consortium: History, development, and the futureHunna J. Watson, Zeynep Yilmaz and Patrick F. Sullivan10. Statistical genetic concepts in psychiatric genomicsDarina Czamara and Divya Mehta11. Opportunities and challenges of machine learning approaches for biomarker signature identification in psychiatryHan Cao and Emanuel Schwarz12. Personalized psychiatry with human iPSCs and neuronal reprogrammingCedric Bardy, Zarina Greenberg, Seth W. Perry and Julio Licinio13. Genetics of alcohol use disorderJill L. Sorcher and Falk W. Lohoff14. Genomics of autism spectrum disordersMargarita Raygada, Paul Grant and Owen M. Rennert15. Genomics of schizophreniaA. Corvin, C. Ormond and A.M. Cole16. Genomics of major depressive disorderDouglas F. Levinson17. Personalized mental health: Artificial intelligence technologies for treatment response prediction in anxiety disordersUlrike Lueken and Tim Hahn18. The genetic architecture of bipolar disorder: Entering the road of discoveriesOlav B. Smeland, Andreas J. Forstner, Alexander Charney, Eli A. Stahl and Ole A. Andreassen19. Genomics of borderline personality disorderFabian Streit, Lucı´a Colodro-Conde, Alisha S.M. Hall and Stephanie H. Witt20. Genetics of obsessive-compulsive disorder and Tourette disorderChristie L. Burton, Csaba Barta, Danielle Cath, Daniel Geller, Odile A. van den Heuvel, Yin Yao, (Obsessive Compulsive Disorder and Tourette Syndrome Working Group of the Psychiatric Genomics Consortium), Valsamma Eapen, Edna Grünblatt and Gwyneth Zai21. Genetics and pharmacogenetics of attention deficit hyperactivity disorder in childhood and adulthoodCristian Bonvicini, Carlo Maj and Catia Scassellati22. Genomics of Alzheimer’s diseaseMargot P. van de Weijer, Iris E. Jansen, Anouk H.A. Verboven, Ole A. Andreassen and Danielle Posthuma23. Current progress and future direction in the genetics of PTSD: Focus on the development and contributions of the PGC-PTSD working groupAngela G. Junglen, Christina Sheerin, Douglas L. Delahanty, Michael A. Hauser, Adriana Lori, Rajendra A. Morey, Caroline M. Nievergelt, Nicole R. Nugent, Jonathan Sebat, Alicia K. Smith, Jennifer A. Sumner, Monica Uddin and Ananda B. Amstadter24. Genomic contributions to anxiety disordersShareefa Dalvie, Nastassja Koen and Dan J. Stein25. Proteomics for diagnostic and therapeutic blood biomarker discovery in schizophrenia and other psychotic disordersDavid R. Cotter, Sophie Sabherwal and Klaus Oliver Schubert26. Molecular biomarkers in depression: Toward personalized psychiatric treatmentAnand Gururajan, John F Cryan and Timothy G Dinan27. Neuroimaging biomarkers of late-life major depressive disorder pathophysiology, pathogenesis, and treatment responseHelmet T. Karim, Charles F. Reynolds, III and Stephen F. Smagula28. Copy number variants in psychiatric disordersFranziska Degenhardt29. Gene-environment interaction in psychiatryHans Jörgen Grabe and Sandra Van der Auwera30. Epigenetics: A new approach to understanding mechanisms in depression and to predict antidepressant treatment responseHelge Frieling, Stefan Bleich and Alexandra Neyazi31. Gene coexpression network and machine learning in personalized psychiatryLiliana G. Ciobanu, Micah Cearns and Bernhard T. Baune32. Pharmacogenomics of bipolar disorderClaudia Pisanu, Alessio Squassina, Martin Alda and Giovanni Severino33. Pharmacogenomics of treatment response in major depressive disorderJoanna M. Biernacka, Ahmed T. Ahmed, Balwinder Singh and Mark A. Frye34. Genomic treatment response prediction in schizophreniaSophie E. Legge, Antonio F. Pardiñas and James T.R. Walters　35. Personalized treatment in bipolar disorderEstela Salagre, Eduard Vieta and Iria Grande36. Genetic testing in psychiatry: State of the evidenceChad A. Bousman, Lisa C. Brown, Ajeet B. Singh, Harris A. Eyre and Daniel J. Müller37. Opportunities and challenges of implementation models of pharmacogenomics in clinical practiceJonathan C.W. Liu, Ilona Gorbovskaya, Chad Bousman, Lisa C. Brown and Daniel J. Müller38. Metabolomics in psychiatryRenee-Marie Ragguett and Roger S. McIntyre39. Real-time fMRI brain-computer interface: A tool for personalized psychiatry?David E.J. Linden40. How functional neuroimaging can be used for prediction and evaluation in psychiatryBeata R. Godlewska and Catherine J. Harmer41. Neuroimaging, genetics, and personalized psychiatry: Developments and opportunities from the ENIGMA consortiumLianne Schmaal, Christopher R.K. Ching, Agnes B. McMahon, Neda Jahanshad and Paul M. Thompson42. Applying a neural circuit taxonomy in depression and anxiety for personalized psychiatryLeanne M. Williams and Andrea N. Goldstein-Piekarski43. Multimodal modeling for personalized psychiatryScott R. Clark, Micah Cearns, Klaus Oliver Schubert and Bernhard T. Baune44. Standardized biomarker and biobanking requirements for personalized psychiatryCatherine Toben, Victoria K. Arnet, Anita Lo, Pamela H. Saunders and Bernhard T. Baune45. Ethical, policy, and research considerations for personalized psychiatryRyan Abbott, Donald D. Chang and Harris A. Eyre46. The future of personalized psychiatryBernhard T. Baune

"This is the first book of its kind I have been exposed to. It is meticulously written and distils a great deal of information into specific chapters. Unless readers have a basic foundation of research techniques and statistical analysis, the book can quickly become very technical. My hope is with future research the findings presented will become more applicable for community clinicians." --Doody