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While the first edition of this book provided a succinct introduction to pediatric neuro-oncology, biological knowledge of childhood CNS tumors has “exploded” over the past few years and a new edition of this textbook is needed to keep it up-to-date.This updated edition will include chapters on cancer predisposition in children with brain tumors, gliomas, embryonal brain tumors, ependymoma, CNS-GCT, targeted therapies in pediatric brain tumors, and long-term sequelae. New developments covered include the following:- Techniques like DNA methylation have improved the diagnostic process, and have led to an integrated diagnosis of histology, ICH and methylation.- Tumor pathways have been detected, which defines more subgroups within a tumor entity, and results in more individualized treatment for the patient.- Therapeutic options outside the standard combination of surgery, chemotherapy, and radiation have either been implemented within the last years, or are currently under consideration.This book will be aimed at pediatric oncologists and neurooncologists, neurosurgeons, radiation oncologists. Chapters detailing quality of life and supportive care will make this 2nd edition a useful resource for nurses, social workers, physiotherapists, and occupational therapists alike.
Katrin ScheinemannDivision of Hematology/Oncology,Children’s Hospital of Eastern SwitzerlandClaudiusstrasse 69006 St. Gallen, Switzerland Eric BouffetDepartment of Hematology/Oncology, The Hospitalfor Sick Children, University of Toronto,555 University Avenue, Toronto, ON, Canada M5G1X8
Introduction.- Presentation of Central Nervous System Tumors.- Epidemiology of Pediatric Primary Central Nervous System Tumors.- Pediatric Neuroimaging.- Neurosurgery.- Pathological Features of Common Pediatric Brain Tumors.- Basic Science of Pediatric Brain Tumors.- Cancer Predisposition in Children with Brain Tumors.- Low Grade Glioma In Children And Adolescents.- Pediatric High Grade Glioma.- Diffuse Midline Glioma – Pons.- Medulloblastoma.- Rare Embryonal Brain tumors.- Ependymoma.- Central Nervous System Germ Cell Tumors (CNS-GCT).- Atypical Teratoid/Rhabdoid Tumors.- Craniopharyngioma.- Rare Tumours Of The Central Nervous System In Childhood.- Radiotherapy.- Chemotherapy. Targeted Therapies in Paediatric Brain Tumours.- High dose chemotherapy/ stem cell transplantation (HDSCT).- Supportive Care.- Long-Term Sequelae.- Neuropsychological Outcomes in Pediatric Brain Tumor Survivors.- Quality of Life.- Palliative Care for Children with Central Nervous System Tumors.- Pediatric Neuro-Oncology in Countries with Limited Resources.- The Use Of Complementary And Alternative Medicine In Pediatric Neurooncology.- The Role of Allied Health Care Professionals in the Care of Paediatric Brain Tumour Patients and their Families.- Our On-line Connection.- The role of social media in the lives of our pediatric neuro-oncology population and their families; and where we intersect.- Neurofibromatosis Type I and Neurofibromatosis Type II.- Pediatric Neuro-Oncology Care in the COVID-19 Era.
