Organic Cation Transporters

• Introduction to the cellular transport of organic cations.- Functional properties of organic cation transporter OCT1, binding of substrates and inhibitors, and presumed transport mechanism.- Pharmacological and toxicological significance of the organic cation transporters OCT and MATE: Drug disposition, interaction and toxicity.- Genetic variability in organic cation transporters: pathophysiological manifestations and consequences for drug pharmacokinetics and efficacy.- Physiological and pathological regulation of transporters for organic cations.- Endocrine and metabolic regulation of transporters for organic cations.- Organic cation transporters (OCTs) as modulators of behavior and mood.- Organic cation transporters as modulators of neurodegeneration and neuroprotection.- Translational relevance of animal models for the study of organic cation transporter function.- Role of transporters for organic cations in plants for environmental cycling of pharmaceutical residues.

“This encyclopedic resource provides extensively detailed, state-of-the-art information about cellular organic cation transporters and their relevance to human function and disease. … This is a magnificent resource for scientists actively engaged in any research related to the biology of organic ion transporters. Every conceivable topic related to these transporters is addressed, making it useful for active researchers in a wide variety of biomedical and biological disciplines.” (David R. Bell, Doody’s Book Reviews, April, 2016)