Nitrogen Heterocycles in Cancer Therapy

Häftad, Engelska, 2025

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Nitrogen Heterocycles in Cancer Therapy explores the vast array of recently discovered nitrogen-containing heterocyclic compounds utilized in combating cancer. This comprehensive work not only highlights the fundamentals of oncology but also explains the intricacies of designing, synthesizing, and understanding the anticancer mechanisms of these compounds. Spanning across 10 chapters, the book explores the principles underlying the design, synthesis, and anticancer mechanisms of nitrogen-containing heterocyclic compounds, drawing from the latest research findings. Its scope extends beyond molecular targeting to encompass the exploration of newly identified heterocyclic compounds with potential anticancer properties.

A significant emphasis is placed on crucial evaluation techniques such as in-vitro cell culture and in-vivo animal models, providing insights into the performance of these compounds in combating cancer. Particularly noteworthy is the inclusion of clinical study reports detailing the efficacy of various drug candidates across different cancer conditions, coupled with an analysis of their global market impact and pharmacoeconomics. Offering profound insights, this book emerges as an indispensable resource for researchers, clinicians, and students alike.

Equips readers with practical solutions to daily challenges in cancer therapy, bridging the gap between organic chemistry and clinical practice
Serves as an essential reference for anyone seeking to navigate the dynamic landscape of cancer therapy using innovative nitrogen-containing compounds
Covers nitrogen heterocycles, encompassing design, synthesis, and mechanisms, providing a thorough understanding of their pivotal role in cancer therapy

Produktinformation

Utgivningsdatum2025-10-27
Mått216 x 276 x undefined mm
Vikt450 g
FormatHäftad
SpråkEngelska
Antal sidor260
FörlagElsevier Science
ISBN9780443331060

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Biologi inom Naturvetenskap och teknik

DR.Sanjeev Sahu received his PhD in Pharmaceutical Sciences at Dr. H. S. Gour Vishwavidyalaya, Saga, India. He is currently Professor at Lovely Professional University. He published dozens of research publications in the SCI/ Scopus indexed renowned international as well as national journals. He also published several books and book chapters. Dr. Ankur Vaidya did his graduation, post-graduation and PhD from Dept. of Pharmaceutical Sciences, Dr. H. S. Gour University, Sagar (M.P.) in 2004, 2008 and 2013 respectively. Dr. Vaidya has a teaching and research experience of many years and is currently working as Asst. Professor in Faculty of Pharmacy UPUMS, Saifai, Etawah (U.P.) India. Dr. Ankur has a key research interest in discovery of new anticancer agents with novel targets and published dozens outstanding publications in various International journals. Dr Vaidya has credited as reviewer of international journals of repute in the field of Pharmaceutical sciences. Dr. Ankur has guided several postgraduate theses and was also the recipient of AICTE-NDF (National Doctorate Fellowship) fellowship for PhD research project. Dr. Vaidya has published nternational book chapters, one International book authored and 1 national book. Dr. Ankur has participated/presented in various National and International conferences.

1. Introduction to heterocyclic nucleus-based nitrogen-containing anticancer compounds2. Three and Four-Member Nitrogen-Containing Heterocyclic Compounds as Anticancer Agents3. Five membered nitrogen-containing heterocyclic compounds (pyrrole and pyrazole derivatives) as anticancer compounds4. Six membered nitrogen-containing heterocyclic compounds (Pyridine, pyrimidine, piperidine and triazine) as anticancer compounds5. Azoles (triazole and imidazole) scaffolds in anticancer drug design6. Purine derivatives in cancer therapy7. Indole scaffolds in anticancer drug discovery8. Benzimidazole, benzothiazole and benzoxazole derivatives as potential anticancer agents9. Quinoline, isoquinoline and quinoxaline derivatives as promising anticancer agents10. Miscellaneous fused heterocyclic compounds (β-lactam derivatives, Carbazoles, Isatin derivatives, Pyrrolo-Benzodiazepines, Pyrido[2,3-d] Pyrimidine Derivatives) as anticancer compounds