Neurodevelopmental Pediatrics

David D. Eisenstat, MD, MA, FRCPC; Professor, Department of Paediatrics, University of Melbourne; Parkville, Victoria Dan Goldowitz, PhD; Scientific Director, NeuroDevNet National Centres of Excellence; Professor and Canada Research Chair; Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute; Department of Medical Genetics; University of British Columbia; 950 West 28th Avenue; Vancouver, British Columbia V5Z 4H4Tim Oberlander, MD, FRCPC; Professor, Department of Pediatrics; BC Children’s Hospital and Child and Family Research Institute; University of British Columbia; 4480 Oak Street; Vancouver, British Columbia V6H 3V4Jerome Y. Yager, MD, FRCPC; Professor, Department of Pediatrics; Stollery Children’s Hospital; Faculty of Medicine and Dentistry; University ofAlberta8440 112 Street, NW; Edmonton, Alberta T6G 2R7

• PART I : OVERVIEW OF CNS DEVELOPMENT AND DISORDERS.- 1. Overview of CNS Organization and Development.- 2. Neural Induction and Regionalization.- 3. Neural Stem Cells, Differentiation, and Migration.- 4. Neurotrophins and Cell Death.- 5. Synaptogenesis.- 6. Axonal Guidance.- 7. Myelination.- 8. Epigenetics.- 9. The Impact of An Adverse Intrauterine Environment on Neurodevelopment.- 10. Stress as a Determinant of Neurodevelopmental Outcomes.- 11. Sex differences in Neurodevelopment and its Disorders.- PART II : AUTISM SPECTRUM DISORDERS.- 12. The History of Autism Spectrum Disorder.- 13. Epidemiology.- 14. An Approach to the Diagnosis of Autism Spectrum.- 15. Cognition.- 16. The Neuroradiology of Autism: Framing neuroimaging investigations of the autistic brain based on the US NIMH Research Domain Criteria.- 17. Neuropathology of Autism.- 18. Genetics and Epigenetics of ASD.- 19. Preclinical Models of Autism Spectrum Disorder.- 20. Biomedical Interventions for Autism Spectrum Disorder.- 21. Interventions in ASD – Psychosocial Interventions for ASD.- PART III : FETAL ALCOHOL SPECTRUM DISORDER.- 22. Clinical Perspectives on the Diagnostic Assessment of Individuals with FASD.- 23. Epidemiology of alcohol consumption among pregnant and childbearing age women and Fetal Alcohol Spectrum Disorder.- 24. Diagnosis.- 25. Magnetic Resonance Imaging in Fetal Alcohol Spectrum Disorder (FASD).- 26. Neuropathological changes in humans with history of prenatal alcohol exposure or diagnosis of fetal alcohol spectrum disorder.- 27. Genetics and Epigenetics of FASD.- 28. Genetic, Epigenetic, and Environmental Influences on Fetal Alcohol Spectrum Disorder: Implications for Diagnosis, Research and Clinical Practice.- 29. Interventions.- PART IV : CEREBRAL PALSY.- 30. Clinical Vignettes.- 31. Epidemiology.- 32. Diagnosis.- 33. Neuroradiology Of Cerebral Palsy.- 34. Neuropathology Of “Cerebral Palsy”.- 35. Genetics and Genomics of Cerebral Palsy.- 36. Pre-Clinical Models of Cerebral Palsy.- 37. Therapeutic Approaches for the Treatment of Cerebral Palsy and Developmental Disability.- PART V : CO-MORBIDITIES IN NEURODEVELOPMENTAL DISORDERS.- 38. Sleep Disorders.- 39. Optimizing Therapy of Seizures in Children and Adolescents with Developmental Disabilities.- 40. Behavioral and Mental Health Disorders (including Attentional Disorders).- 41. Role of Gender and Neurodevelopmental Disabilities.- 42. A non‐categorical approach to childhood neurodisability: concepts, evidence and implications for clinical practice, organization of services, teaching, and research.- 43. Pain and Symptom Management in Neurodevelopmental Disorders: Sensory and Nociceptive Function/Pain and Symptom Management.- 44. Pharmacology, Psychopharmacology and Adverse Drug Reactions.- 45. Developmental origins, differential susceptibility and resilience in neurodevelopmental disorders.- PART VI : NEURODEVELOPOMENTAL DISORDERS IN THE CONTEXT OF FAMILIES.- 46. Children with Neurodevelopmental Disabilitiesand the Right to Health.- 47. Patient Navigation: Core Concepts and Relevance to the Field of Pediatric Neurodisability.- 48. Evaluating the Economic Impact of Neurodevelopmental Disability Intervention on the Family and Community.- PART VII : RESOURCES.- 49. Using Large-Scale Population-Based Data.- 50. Tools for Knowledge Dissemination and Translation to help your journey from research to impact.