Neurobiology of Nociceptors

Inbunden, Engelska, 1996

Av Carlos Belmonte, Fernando Cervero, University of Alicante) Belmonte, Carlos (Professor, Professor, University of Alcala de Henares) Cervero, Fernando (Professor, Professor

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This is the first comprehensive review of all aspects of nociceptor function, including the structure of nociceptor endings, their neurochemistry, and evolutionary considerations. It deals with the functional properties of nociceptors innervating different organs and the biophysical mechanisms underlaying the transduction process in nociceptors. There are sections on how nociceptor function is modified by nerve injury and regeneration and on its physiopathology.This is an essential reference for researchers in neuroscience and pharmacology, and clinicians working in pain management.

Produktinformation

Utgivningsdatum1996-08-01
Mått175 x 251 x 35 mm
Vikt1 225 g
FormatInbunden
SpråkEngelska
Antal sidor542
FörlagOUP OXFORD
ISBN9780198523345

Tillhör följande kategorier

Smärta och smärtbehandling inom Medicin
Biovetenskap inom Naturvetenskap och teknik
Neurologi och klinisk neurofysiologi inom Medicin
Farmakologi inom Medicin

Preface ; Principles of classification and nomenclature relevant to studies of nociceptive neurones ; PART 1: BASIC ASPECTS OF NOCICEPTOR FUNCTION ; 1. Pain and the discovery of nociceptors ; 2. Structure of nociceptor 'endings' ; 3. Neurochemistry of cutaneous nociceptors ; 4. Comparative and evolutionary aspects of nociceptor function ; PART 2: NOCICEPTORS AND THE SIGNALLING OF INJURY ; 5. Cutaneous nociceptors ; 6. Corneal nociceptors ; 7. Nociceptors in skeletal muscle and their reaction to pathological tissue changes ; 8. Neurobiology of articular nociceptors ; 9. Visceral nociceptors ; PART 3: TRANSDUCTION MECHANISMS AND SENSITIZATION ; 10. Signal transduction in nociceptors: general principles ; 11. Chemical excitation and sensitization in nociceptors ; 12. Intracellular messengers and signal transduction in nociceptors ; 13. Sensitization of polymodal receptors ; PART 4: FUNCTIONS OF NOCICEPTORS ; 14. Functional properties of human cutaneous nociceptors and their role in pain and hyperalgesia ; 15. Neural mechanisms of primary hyperalgesia ; 16. Secondary cutaneous dysaesthesiae ; 17. Efferent function of nociceptors ; 18. Nociceptors and neuroimmune interactions ; PART 5: NOCICEPTOR PLASTICITY ; 19. Development of the nociceptor phenotype: role of nerve growth factor ; 20. Properties of regenerated nociceptor afferents ; 21. Pathophysiology of human nociceptor function

a compilation of detailed chapters, which attempts and succeeds as a thorough review of the literature pertaining to nociceptors up to 1995 ... the book is well organized and carefully written and edited so that it remains readable and thought-provoking throughout ... a comprehensive source text that provides appropriately referenced key concepts of contemporary research involving nociceptors, and brings into focus current perspectives for understanding their role in pain perception