Natural Products Analysis

Vladimir Havlicek is a Professor of Analytical Chemistry in the Institute of Microbiology of the Academy of Sciences of the Czech Republic. His laboratory uses analytical tools to characterize molecular structure. He has worked in the field of natural products for over 20 years. Dr. Havlicek is on the editorial or advisory boards of several leading analytical journals and has published over 130 papers in peer-reviewed journals.Jaroslav Spizek is a Professor of Molecular and Cell Biology and Genetics in the Institute of Microbiology of the Academy of Sciences of the Czech Republic, where he was director between1992-2000. He has worked in the field of antibiotics for 50 years. In 2011, he became an Elected Fellow of the American Academy of Microbiology. Professor Spizek has published 98 peer-reviewed papers and edited two books.

• Preface ixContributors xi1. Natural Products Analysis: Instrumentation, Methods, and Applications 1Vladimír Havlíèek and Jaroslav Spí?ek2. The Need for New Antifungal and Antimalarial Compounds 9Jaroslav Spí?ek and Arnold L. Demain3. Emerging Instrumental Methods for Antimicrobial Resistance and Virulence Testing 25Plamen A. Demirev4. Plant and Marine Sources: Biological Activity of Natural Products and Therapeutic Use 43Amedeo Amedei and Elena Niccolai5. Emerging Trends for Stimulating the Discovery of Natural Products 115Navid Adnani, Gregory A. Ellis, Thomas P. Wyche, Tim S. Bugni, Jason C. Kwan, and Eric W. Schmidt6. Advances and Challenges in Optical Molecular Spectroscopy Including Surface Plasmon Resonance-Based Methods for Bioanalysis 163Pavel Matìjka, Blanka Vlèková, Lucie Bednárová, and Petr Malon7. Advanced Techniques for NMR Analysis of Complex Biological Mixtures—From Simple NMR to Hyphenated Techniques 239Helena Pelantová, Simona Bártová, and Marek Kuzma8. Advances in X-Ray Diffraction: Implications to the Pharmaceutical Industry 285Alexandr Jegorov and Michal Hušák9. Laser Ablation Inductively Coupled Plasma Mass Spectrometry as a Tool in Biological Sciences 313Michaela Vašinová Galiová, Jan Havliš, and Viktor Kanický10. Imaging Mass Spectrometry, Metabolism, and New Views of the Microbial World 349B. Christopher Hoefler and Paul D. Straight11. Structural Separations for Natural Product Characterization by Ion Mobility–Mass Spectrometry: Fundamental Theory to Emerging Applications 397Sarah M. Stow, Nichole M. Lareau, Kelly M. Hines, C. Ruth McNees, Cody R. Goodwin, Brian O. Bachmann, and John A. McLean12. High-Resolution Tandem Mass Spectrometry for Nonribosomal Peptide and Polyketide Analysis 433Rebecca H. Wills, Manuela Tosin, and Peter B. O’Connor13. Natural Product Drug Discovery and Analysis Using Mass Spectrometry and Affinity-Based Technologies 475Evelyn H. Wang and Kevin A. Schug14. Glycosylated Ribosomally Synthesized Peptide Toxins: Discovery, Characterization, and Applications 507Gillian E. Norris and Mark L. Patchett15. Using Ultrahigh-Resolution Mass Spectrometry to Unravel the Chemical Space of Complex Natural Product Mixtures 545Constanze Müller, Mourad Harir, Norbert Hertkorn, Basem Kanawati, Dimitrios Tziotis, and Philippe Schmitt-Kopplin16. Functional Amyloid Fibrils: Lessons from Microbes 571Sally L. Gras and Dennis ClaessenIndex 601

“Every chapter, even those that depart somewhat from the declared remit, is packed with information most of it, as I said at the beginning, representing the cutting edge of the subject.  I cannot recommend it too highly.”  (Chromatographia, 1 May 2015)