Nanomedicine

Yujun Song, PhD, is Professor at the School of Mathematics and Physics, University of Science and Technology Beijing, China. He has conducted and published extensive research in bio-nanotechnology and biomedical engineering.

• Preface xv1 State of the Art in Nanomedicine 1Yujun Song and Wei Hou1.1 Intractable Diseases and Development of the Related Novel Therapy and Medicines 11.2 Key Features of Nanomedicines 41.3 Nanotechnology Translational Nanomedicine: Emergence and Progress 61.4 Interdisciplinary Features of Nanomedicines: Multi-mode and Multi-function Features Promoting Nanomedicine-mediated Immunotherapy and/or Physical Field Ablation Therapy for Subversive Therapy 121.5 Future Development of Nanomedicines by Coupling Advanced Biomedicines (Including Biochemistry and Biophysics), Modern Physicochemical Technologies, and Artificial Intelligence Technology 272 Fundamentals in Nanomedicine 49Xiangrong Song, Mengran Guo, Zhongshan He, Xing Duan, and Wen Xiao2.1 Design Theory of Nanomedicines 492.2 Progress in the Controlled Synthesis of Nanomaterials 552.3 Progress in the Surface Modification and Functionalization of Nanomaterials for Nanomedicines 603 Nanomedicine for Antitumors 73Qiong Wu, Xinzhu Yang, Ruixue Zhu, and Yujun Song3.1 Introduction 733.2 Liposomal Nanoparticles 753.3 Polymeric Nanoparticles 783.4 Inorganic Nanoparticles 823.5 Mixture (Hybrid) Nanoparticles 903.6 Cell Membrane Coating Nanotechnology 933.7 Challenges and Current Limitations 943.8 Conclusions 964 Nanomedicine for the Treatment of Nervous System Diseases 113Xiaojian Cui and Yujun Song4.1 Concepts and Types of Nanomedicines for Nervous System Diseases 1134.2 Therapeutical Methods for Nervous System Diseases and Features of Current Nanomedicines 1144.3 Synthesis Methods and Typical Examples (Including Clinical Trial) of Polymer-based Nanomedicines for Nervous System Diseases 1164.4 Inorganic-based Nanomedicines: Synthesis Methods and Typical Application (Including Clinical) 1174.5 Metallic-based Nanomedicines: Synthesis Methods and Typical Application (Including Clinical) 1224.6 Multifunctional Nanomedicines for Nervous System Diseases 1255 Nanomaterial Translational Nanomedicine for Anti-HIV and Anti-bacterial 131Hao Luo and Yujun Song5.1 Concepts, Anti-HIV Theory, and Types and Features of Current Nanomedicines 1325.2 Polymer-based Nanomedicines: Synthesis Methods and Typical Application 1425.3 Inorganic-based Nanomedicines: Synthesis Methods and Typical Application 1465.4 Metallic-based Nanomedicines: Synthesis Methods and Typical Application 1485.5 Multi-functional (Target) Nanomedicines 1505.6 Future Development 1526 Nanomedicine for Next-generation Dermal Management 157Haibin Wu, Qian Chen, and Shen Hu6.1 Introduction 1576.2 Nano-biomaterials-based Therapeutics forWound Healing 1596.3 Nano-biomaterials for Imaging and Monitoring of Cutaneous Wounds 1766.4 Conclusion and Future Outlook 1817 Nanomedicine for Targeting Delivery of Gene and Other DNA/RNA Therapies Based Viruses Engineering 197Xiangrong Song, Mengran Guo, Zhongshan He, Xing Duan, and Wen Xiao7.1 Targeting Delivery of Gene Therapies to the Tumors 1987.2 Targeting Delivery of Gene-based Nanovaccines to the Spleen 1997.3 Targeting Delivery of Gene-based Nanovaccines to the LNs 2007.4 Targeting Delivery of Gene-based Nanomedicines to the Liver 2007.5 Targeting Delivery of Gene-based Nanomedicines to the Lung 2007.6 Targeting Delivery of Gene-based Nanomedicines to the Brain 2028 Nanomedicine for Bio-imaging and Disease Diagnosis 207Ziqi Wang and Yujun Song8.1 Concepts, Types, and Features of Current Nanoprobes 2078.2 Synthesis Methods 2148.3 Typical Application Examples in the Disease Diagnosis and Study of Biological Events 2198.4 Future Development 2249 Magnetic Nanoparticles and Their Applications 227Xiuyu Wang and Yuting Tang9.1 Introduction 2279.2 Classification of Magnetic Nanoparticles 2289.3 Biomedical Applications 2369.4 Conclusion and Outlook 24210 Nanomedicine-mediated Immunotherapy 245Wei Hou and Yujun Song10.1 Immune System and Immune Response 24510.2 Mechanism of Tumor Immunotherapy 24710.3 Mechanism of Nanomedicine-enhancing Immunotherapy 24810.4 Immunological Applications of Nanomedicines 25210.5 Summary and Outlook 26311 Nanomedicine-mediated Ultrasound Therapy 269Qingwei Liao, Yaoyao Liao, and Wei Si11.1 Concept, Therapy Theory, and Devices 26911.2 Nanomedicine Synthesis with Ultrasound Field Response 27411.3 Application Examples 27512 Nanomedicine-mediated Photodynamic and/or Photothermal Therapy 279Shangqing Jing and Yujun Song12.1 Photodynamic and Photothermal Mechanism for Anti-cancer 28112.2 Nanomaterial-based PSs (Nano-PSs) for PDT 28312.3 Photodynamic and Photothermal Synergistic Therapy 29112.4 Opportunities and Challenges 29212.5 Summary 29313 Nanomedicine-mediated Pulsed Electric Field Ablation Therapy 299Xinzhu Yang, Qiong Wu, Ruixue Zhu, and Yujun Song13.1 Introduction 29913.2 Concept, Therapy Theory, and Devices 30213.3 Synthesis of Nanomedicine with Electric Field Response 31213.4 Application Examples 32213.5 Conclusion 32314 Nanomedicine-mediated Magneto-dynamic and/or Magneto-thermal Therapy 329Yangfei Wang and Yujun Song14.1 Concepts, Treatment Theories, and Methods 32914.2 Treatment Theories and Methods 33014.3 Magnetic Field-responsive Nanomedicine Synthesis 33314.4 Applications 33715 Nanomedicine-mediated Radiotherapy for Cancer Treatment 341Ruixue Zhu and Yujun Song15.1 Concept, Therapy Theory, and Devices 34115.2 Nanomaterials as Radiosensitizers for Radiation Therapy 34715.3 Nanomaterials Delivering Radioisotope for Internal Radioisotope Therapy 35815.4 Nanomedicine Synthesis with Radio/Nuclear Radiation Response 36215.5 Conclusion and Prospects 36416 Nanomedicine Conjugating with AI Technology and Genomics for Precise and Personalized Therapy 371Lin Liu, Siyu Chen, and Sen Zhang16.1 Concept 37116.2 Genomics of Nanomedicine 37416.3 Artificial Intelligence Technology in Nanomedicine Development 37716.4 Artificial Intelligence Facilitates Precise and Personalized Nanomedicine Based on Genomics 37917 Microfluidic Conjugating AI Platform for High-throughput Nanomedicine Screening 385Xing Huang, Wenya Liao, Zhongbin Xu, and Yujun Song17.1 Introduction 38517.2 Microfluidic Technologies for Medicine Development 38617.3 Microfluidic Preparation of Nanomedicines 39117.4 Microfluidic High-throughput Drug Screening 39617.5 AI-assisted Microfluidic Development of Nanomedicine 40017.6 Conclusions and Perspectives 402References 404Index 413