Muscle 2-Volume Set

Fundamental Biology and Mechanisms of Disease

Inbunden, Engelska, 2012

2 319 kr

Beställningsvara. Skickas inom 5-8 vardagar

Fri frakt för medlemmar vid köp för minst 249 kr.

A valuable study of the science behind the medicine, Muscle: Fundamental Biology and Mechanisms of Disease brings together key leaders in muscle biology. These experts provide state-of-the-art insights into the three forms of muscle--cardiac, skeletal, and smooth--from molecular anatomy, basic physiology, disease mechanisms, and targets of therapy. Commonalities and contrasts among these three tissue types are highlighted. This book focuses primarily on the biology of the myocyte.Individuals active in muscle investigation--as well as those new to the field--will find this work useful, as will students of muscle biology. In the case of hte former, many wish to grasp issues at the margins of their own expertise (e.g. clinical matters at one end; molecular matters at the other), adn this book is designed to assist them. Students, postdoctoral fellows, course directors and other faculty will find this book of interest. Beyond this, many clinicians in training (e.g. cardiology fellows) will benefit.

Produktinformation

Utgivningsdatum2012-08-25
Mått216 x 276 x undefined mm
Vikt4 870 g
FormatInbunden
SpråkEngelska
Antal sidor1 528
FörlagElsevier Science
ISBN9780123815101

Tillhör följande kategorier

Klinisk medicin och internmedicin inom Medicin
Fysiologi inom Medicin

Dr. Hill is a cardiologist-scientist whose research strives to decipher mechanisms of structural, functional, and electrical remodeling of the heart. He earned M.D. and Ph.D. degrees from Duke University, conducted postdoctoral scientific training with Jean-Pierre Changeux at the Institut Pasteur in Paris, and pursued clinical training in Internal Medicine and Cardiology at Brigham and Women's Hospital, Harvard Medical School. Dr. Hill served on faculty at the University of Iowa for 5 years before moving in 2002 to UT Southwestern as Chief of Cardiology and Director of the Harry S. Moss Heart Center. Dr. Hill's honors include election to the Association of University Cardiologists and the Association of American Physicians. Dr. Hill maintains an active clinical practice focusing on general cardiology, hypertension, and heart failure. Dr. Olson has dedicated his career to deciphering mechanisms that control muscle gene regulation and development. He received B.A. and Ph.D. degrees from Wake Forest University. After postdoctoral training with Luis Glaser at Washington University School of Medicine, he joined the Department of Biochemistry and Molecular Biology at the M. D. Anderson Cancer Center in 1984 and became Professor and Chairman in 1991. In 1995, he founded the Department of Molecular Biology at UT Southwestern. Dr. Olson has received numerous prestigious awards and honors. He is a member of the American Academy of Arts and Sciences, and its Institute of Medicine.

Part 1: Introduction1. An Introduction to Muscle2. A History of MusclePart II: Cardiac MuscleSection A: Basic Physiology3. Cardiac Myocyte Specification and Differentiation4. Transcriptional Control of Cardiogenesis5. Cardiomyocyte Ultrastructure6. Overview of CArdiac Muscle Physiology7. Ionic Fluxes and Genesis of the Cardiac Action Potential8. G-Protein-Coupled Receptors in the Heart9. Receptor Tyrosine Kinases in Cardiac Muscle10. Communication in the Heart: Cardiokines as Mediators of a Molecular Social Network11. Calcium Fluxes and Homeostasis12. Excitation-Contraction Coupling in the Heart13. Role of Sarcomeres in Cellular Tension, Shortening, and Signaling in Cardiac Muscle14. Cardiovascular Mechanotransduction15. Cardiomyocyte Metabolism: All Is in Flux16. Transcriptional Control of Striated Muscle Mitochondrial Biogenesis and Function17. Mitochondrial Morphology and Function18. Genetics and Genomics in Cardiovascular Gene Discovery19. Cardiovascular Proteomics: Assessment of Protein Post-Translational ModificationsSection B: Adaptations and Response20. Adaption and Responses: Myocardial Innervations adn Neural Control21. Regulation of Cardiac Systolic Function and Contractility22. Intracellular Signaling Pathways in Cardiac Remodeling23. Oxidative Stress and Cardiac Muscle24. Physiologic and Molecular Responses of the Heart to Chronic Exercise25. Epigenetics in Cardiovascular Biology26. Cardiac MicroRNAs27. Protein Quality Control in Cardiomyocytes28. Cardioprotection29. Cardiac Fibrosis: Cellular and Molecular Determinants30. Autophagy in Cardiac Physiology and Disease31. Programmed Cardiomyocyte Death in Heart Disease32. Wnt and Notch: Potent Regulators of Cardiomyocyte Specification, Proliferation, and DifferentiationSection C: Myocardial Disease33. Congenital Cardiomyopathies34. Genetics of Congenital Heart Disease35. Mechanisms of Stress-Induced Cardiac Hypertrophy36. Ischemic Heart Disease37. The Pathophysiology of Heart Failure38. The Right Ventricle: Reemergence of the Forgotten Ventricle39. Mammalian Myocardial Regeneration40. The Structural Basis of Arrhythmia41. Molecular and Cellular Mechanisms of Cardiac Arrhythmias42. Genetic Mechanisms of Arrhythmia43. Infiltrative adn Protein Misfolding Myocardial Diseases44. Cardiac Aging: From Humans to Molecules45. Adrenergic Receptor Polymorphisms in Heart Failure46. Cardiac Gene Therapy47. Protein Kinases in the Heart: Lessons Learned from Targeted Cancer Therapeutics48. Cell Therapy for Cardiac Disease49. Chemical Genetics of Cardiac Regeneration50. Device Therapy for Systolic Ventricular Failure51. Novel Therapeutic Targets and Strategies against Myocardial DiseasesPart III: Skeletal MuscleSection A: Basic Physiology52. Skeletal Muscle Development53. Skeletal Muscle: Architecture of Membrane Systems54. The Vertebrate Neuromuscular Junction55. Neuromuscular Interactions that Control Muscle Function and Adaptation56. Control of Resting CA2+ Concentration in Skeletal Muscle57. Skeletal Muscle Excitation-Contraction Coupling58. The Contractile Machinery of Skeletal Muscle59. Skeletal Muscle Metabolism60. Skeletal Muscle Fiber TypesSection B: Adaptations and Response61. Regulation of Skeletal Muscle Development and Function by microRNAs62. Musculoskeletal Tissue Injury and Repair: Role of Stem Cells, Their Differentiation, and Paracrine Effects63. Immunological Responses to Muscle Injury64. Skeletal Muscle Adaptation to Exercise65. Skeletal Muscle Regeneration66. Skeletal Muscle Dystrophin-Glycoprotein Complex and Muscular DystrophySection C: Skeletal Muscle Disease67. Statin-Induced Muscle Toxicity: Clinical and Genetic Determinants of Risk68. Myotonic Dystrophy69. Facioscapulohumeral Muscular Dystrophy: Unraveling the Mysteries of a Complex Epigenetic Disease70. ECM-Related Myopathies and Muscular Dystrophies71. Molecular Pathogenesis of Skeletal Muscle Abnormalities in Marfan Syndrome72. Diseases of the Nucleoskeleton73. Channelopathies of Skeletal Muscle Excitability74. Thick and Thin Filament Proteins: Acquired adn Hereditary Sarcomeric Protein Diseases75. Metabolic and Mitochondrial MyopathiesSection D: Therapeutics76. Gene Therapy of Skeletal Muscle Disorders Using Viral Vectors77. Cell-Based Therapies in Skeletal Muscle Disease78. Immunological Components of Genetically Inherited Muscular Dystrophies: Duchenne Muscular Dystrophy and Limb-Girdle Muscular Dystrophy79. Myostatin: Regulation, Function, and Therapeutic Applications80. Insulin-Like Growth Factor I Regulation and Its Action in Skeletal Muscle Growth and Repair81. Novel Targets and Approaches to Treating Skeletal Muscle DiseasePart IV: Smooth MuscleSection A: Basic Physiology82. Development of the Smooth Muscle Cell Lineage83. Smooth Muscle Myocyte Ultrastructure84. Potassium, Sodium, and Chloride Channels in Smooth Muscle Cells85. G-Protein-Coupled Receptors in Smooth Muscle86. Calcium Homeostasis and Signaling in Smooth Muscle87. Regulation of Smooth Muscle ContractionSection B: Heterogeneities88. Heterogeneity of Smooth Muscle89. Microcirculation90. Uterine Smooth MuscleSection C: Adaptations and Response91. Oxidative Stres, Endothelial Dysfunction, and Its Impact on Smooth Muscle Signaling92. Hemodynamic Control of Vascular Smooth Muscle Function93. Myogenic Tone and Mechanotransduction94. Cell-Cell Communication Through Gap Junctions95. Vascular Smooth Muscle Cell Phenotypic Adaptation96. Molecular Pathways of Smooth Muscle DiseaseSection D: Smooth Muscle Disease97. Genetic Variants in Smooth Muscle Contraction and Adhesion Genes Cause Thoracic Aortic Aneurysms and Dissections and Other Vascular Diseases98. Vascular Smooth Muscle Cell Remodeling in Atherosclerosis and Restenosis99. Arterial Hypertention100. Diabetic Vascular Disease101. Vascular Mechanisms of Hypertension in the Pathophysiology of Preeclampsia102. Erectile Dysfunction103. Smooth Muscle in the Normal and Diseased Pulmonary Circulation104. Airway Smooth Muscle and Asthma105. Aging106. Vascular Calcification107. Smooth Muscle Progenitor Cells: A Novel Target for the Treatment of Vascular Disease?108. Smooth Muscle: Novel Targets and Therapeutic Approaches

"This two-volume set is distinguished by its emphasis on normal muscle function as well as changes evident in pathology or disease. Therapeutic interventions end each section, but the science comes first. Organization of 108 chapters is in sections on cardiac muscle (basic physiology, adaptations and response, myocardial disease); skeletal muscle (basics and adaptations, disease, and therapeutics); and smooth muscle (physiology, heterogeneities, adaptations and response, and disease). Editors Hill and Olson (both: U. of Texas Southwestern Medical Center) have shepherded the work of contributors based mostly in the US, with a few from Europe." --Reference & Research Book News October 2012