Multiple Sclerosis As A Neuronal Disease

• PrefaceContributorsI Structure, Molecular Organization, and Function of Myelinated Axons 1. The Structure of Myelinated Axons in the CNS 2. Dialogues: Communication Between Axons and Myelinating Glia 3. Molecular Specializations at the Glia-Axon Interface 4. Potassium Channel Organization of Myelinated and Demyelinated Axons 5. The Roles of Potassium and Calcium Channels in Physiology and Pathophysiology of AxonsII Neuronal Concomitants of Demyelination 6. The Conduction Properties of Demyelinated and Remyelinated Axons 7. Altered Distributions and Functions of Multiple Sodium Channel Subtypes in Multiple Sclerosis and Its Models 8. Na+ Channel Reorganization in Demyelinated Axons 9. Ion Currents and Axonal Oscillators: A Possible Biophysical Basis for Positive Signs and Symptoms in Multiple Sclerosis 10. Clinical Pharmacology of Abnormal Potassium Channel Organization in Demyelinated AxonsIII Multiple Sclerosis as a Neurodegenerative Disease 11. Pathology of Neurons in Multiple Sclerosis 12. Axonal Degeneration in Multiple Sclerosis: The Histopathological Evidence 13. Natural History of Multiple Sclerosis: When Do Axons Degenerate?IV Measurement of Neuronal Changes in the Clinical Domain 14. Brain Atrophy as a Measure of Neurodegeneration and Neuroprotection 15. MRI–Clinical Correlations in Multiple Sclerosis: Implications for Our Understanding of Neuronal Changes 16. Electrophysiological Correlates of Relapse, Remission, Persistent Sensorimotor Deficit, and Long-Term Recovery Processes in Multiple SclerosisV Cellular and Molecular Mechanisms of Axonal Degeneration in Multiple Sclerosis 17. Inflammation and Axon Degeneration 18. Nitric Oxide and Axonal Pathophysiology 19. Molecular Mechanisms of Calcium Influx in Axonal Degeneration 20. Axonal Damage and Neuron Death in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis: The Role of Calpain 21. Mutations of Myelination-Associated Genes That Affect Axonal IntegrityVI Other Aspects of Neuronal Injury in Multiple Sclerosis 22. Neuronal Blocking Factors in Demyelinating Diseases 23. Evidence for Neuronal Apoptosis in Demyelinating CNS DiseasesVII Lessons from the Peripheral Nervous System 24. Mechanisms Underlying Wallerian Degeneration 25. AMAN: What It Teaches Us about Mechanisms Underlying Axonal Injury VIII Prognosis, Reparative Mechanisms, and Therapeutic Approaches 26. Axonal Degeneration as a Predictor of Outcome in Neurological Disorders 27. Remyelination as Neuroprotection 28. Transplantation of Peripheral-Myelin-Forming Cells to Repair Demyelinated Axons 29. Blocking the Axonal Injury Cascade: Neuroprotection in Multiple Sclerosis and Its Models 30. Functional Brain Reorganization and Recovery after Injury to White MatterIndex

"The editor and many excellent contributors present abundant evidence for importance of the neuronal component of multiple sclerosis. ...There is no doubt that Steve Waxman's forceful book will substantially influence the field by providing a strong impetus to research on the neuronal question in multiple sclerosis."--NATURE NEUROSCIENCE (February 2006)"...this book offers an excellent overview of the biology of the axon, the clinical assessment of axonal damage, and the mechanisms contributing to axonal damage. ...The book should provide valuable reading for the student of neurology as well as for those less familiar with the subtleties of the axon. It will also be of value to those knowledgeable about multiple sclerosis who are beginning to move into clinical studies of neuroprotection and repair."--Henry McFarland in THE NEW ENGLAND JOURNAL OF MEDICINE (September 22, 2005)"'MS as a Neuronal Disease' by Waxman and coauthors is a textbook long overdue. ...This book makes essential reading for neuroscientists and neurologists"--Archives of Neurology (December 2005)