Modulation of Presynaptic Calcium Channels

Inbunden, Engelska, 2013

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A number of therapeutic drugs target the Ca2+ channel complex, including the anti-epileptic gabapentinoid and analgesic ziconotide drugs and the pharmaceutical industry is searching for Ca2+ channel blocking drugs, particularly in the pain, epilepsy, ataxia and migraine areas.

Produktinformation

Utgivningsdatum2013-05-08
Mått155 x 235 x 25 mm
Vikt735 g
FormatInbunden
SpråkEngelska
Antal sidor365
Upplaga2013
FörlagSpringer
ISBN9789400763333

Tillhör följande kategorier

Spatial and temporal regulation of Ca2+ channels.- Neuronal functions of auxiliary calcium channel subunits.- Reciprocal regulation of neuronal calcium channels by synaptic proteins.- Molecular architecture of Ca2+ channel complexes organized by β subunits in presynaptic active zones.- Control of CaV2 calcium channels and neurosecretion by heterotrimeric G protein coupled receptors.- Regulation of CaV2 channels by small GTPases.- Protein interaction partners of Cav2.3 R-type voltage-gated calcium channels.- Voltage-gated calcium channel signaling to the nucleus.- Presynaptic Ca2+ influx and its modulation at auditory calyceal terminals.- Use of synthetic Ca2+ channel peptides to study presynaptic function.- Impact of a loss-of-function P/Q type Ca2+ channel mutation on excitatory synaptic control of cerebellar Purkinje neurons.- CaV2.1 (P/Q) voltage activated Ca2+ channels and synaptic transmission in genetic and autoimmune diseases.- Splicing and editing to customize CaV channel structures for optimal neural function.- Presynaptic calcium channels as drug targets for pain.- Sensory pathway modulation by calcium channel a2d1 subunit.