Del 610 - Methods in Enzymology

Modern Approaches in Drug Discovery

Inbunden, Engelska, 2018

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Modern Approaches in Drug Discovery, Volume 611, the latest release in the Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters on topics such as Target Identification and Validation, Cell Painting/High Content Imaging, Target ID using chemical probes, Mining the microbiome for targets, Data driven approaches for diversity and drug-likeness, Affinity-based screening, Fragment screening (X-ray), Array-based approaches, Hit-to-lead: assessment and improvement of drug-like properties, Hit assessment and prioritization, Lead Optimization: fine tuning and risk mitigation, and more.

Provides the authority and expertise of leading contributors from an international board of authors
Presents the latest release in the Methods in Enzymology series
Updated release includes the latest information on the Intrinsically Disordered Proteins

Produktinformation

Utgivningsdatum2018-11-01
Mått152 x 229 x undefined mm
Vikt770 g
FormatInbunden
SpråkEngelska
SerieMethods in Enzymology
Antal sidor337
FörlagElsevier Science
MedarbetareLesburg,Charles
ISBN9780128153833

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1. Risk Management in Early Discovery Medicinal Chemistry Gurpreet Singh, Jayme L. Dahlin and Michael A. Walters2. Target Identification Using Chemical ProbesMoses Moustakim, Suet Ling Felce, Nancy Zaarour, Gillian Farnie, Fiona E. McCann and Paul E. Brennan3. Mining the Microbiome for Drug TargetsQi Wang, Fangming Yang and Huijue Jia4. Screening Library DesignStephanie Kay Ashenden5. Design of a Fragment Screening LibraryAshley Taylor, Bradley C. Doak and Martin J. Scanlon6. Genetically Encoded Cyclic Peptide Libraries: From Hit to Lead and BeyondJacob Valentine and Ali Tavassoli7. A Guide to Run Affinity Screens Using Differential Scanning Fluorimetry and Surface Plasmon Resonance AssaysChristian Bergsdorf and Kirk Wright8. Second-Harmonic Generation (SHG) for Conformational Measurements: Assay Development, Optimization, and ScreeningTracy A. Young, Ben Moree, Margaret T. Butko, Bason Clancy, Mary Geck Do, Tarun Gheyi, John Strelow, Juan J. Carrillo and Joshua Salafsky9. An Array-Based Ligand Discovery Platform for Proteins With Short Half-LivesBecky S. Leifer, Shelby K. Doyle, André Richters, Helen L. Evans and Angela N. Koehler10. High Content, Phenotypic Assays and Screens for Compounds Modulating Cellular Processes in Primary NeuronsMiklos Kepiro, Boglarka H. Varkuti and Ronald L. Davis11. Achieving a Good Crystal System for Crystallographic X-Ray Fragment ScreeningPatrick M. Collins, Alice Douangamath, Romain Talon, Alexandre Dias, Jose Brandao-Neto, Tobias Krojer and Frank von Delft12. Hit-to-Lead: Hit Validation and AssessmentKirk E. Hevener, JinHong Ren, Russell Pesavento, Kiira Ratia, Hyun Lee and Michael E. Johnson13. Knowledge-Based Approaches to Off-Target ScreeningDaniel R. McMasters