Models of Neurodegenerative Diseases

Jan Cendelin, MD, is Associate Professor, Department of Pathophysiology, Faculty of Medicine in Pilsen, Charles University, Plzen, Czech RepublicJan Tuma, PhD, is Assistant Professor, Department of Pathophysiology, Faculty of Medicine in Pilsen, Charles University, Plzen, Czech RepublicMario Manto, MD, is Professor of Neuroanatomy, University of Mons, and Head of the Department of Neurology at the CHU-Charleroi, Belgium. He is Series Editor for the Springer series, Contemporary Clinical Neuroscience

• Introduction.- Mechanisms of neurodegeneration and their modelling.- Animal models.- In vitro models.- Computational models.- Genetically modified organisms.- Applications and limitations of the models: an overview.- Examination of behavior cognition and motor function in animal model.- Electrophysiological approaches to examine animal models of neurodegenerative diseases.- Histological approaches to investigate animal models of neurodegenerative diseases.- Biochemical and molecular biology approaches to investigate models of neurodegenerative diseases.-  Models of the Alzheimers disease and other amyloidopathies.- Models of tauopathies.- Models of synucleinopathies.- Models of the Huntington disease and other polyglutaminopathies.- Models of degenerative ataxias.- Models of the motor neuron disorders.- Spinal cord disorders.- Models of polyneuropathies.- Sensory system degenerations.- Models of mitochondrial.- neurodegenerative diseases.- Models of storage diseases.- Models of other neuropathologies with contribution of neurodegeneration.- lTesting pharmacotherapy in preclinical models, principles of translational approach.- Experimental therapeutic approaches molecular and genetic.- Experimental therapeutic approaches  neurostimulation.- Investigation of neurotransplantation and regenerative therapy in preclinical models.