Microglial Advances in Neurodegenerative Diseases

Microglial Advances in Neurodegenerative Diseases, Volume 170 of Advances in Immunology series, presents current developments and comprehensive reviews focused on the role of microglia and neuroinflammation in neurological and psychiatric disorders. This volume brings together contributions from leading researchers, offering up-to-date insights into microglial biology in health and disease, as well as their involvement in major neurodegenerative conditions.

Chapters explore microglial interactions with key pathological proteins, including tau and amyloid-beta, mechanisms of neuroinflammation, and receptor-mediated signaling pathways. Additional contributions highlight advances in induced pluripotent stem cell-derived microglia as experimental and therapeutic platforms, neuromodulation strategies, and emerging perspectives on Parkinson’s disease, Alzheimer’s disease, amyotrophic lateral sclerosis, and psychiatric disorders. Together, these chapters provide a comprehensive overview of recent progress and emerging directions in microglial research and neurodegeneration.

• Presents current advances and authoritative reviews on microglial biology and neuroinflammation
• Includes contributions from leading international experts in neuroscience and neurodegenerative research
• Covers microglial roles in Alzheimer’s disease, Parkinson’s disease, ALS, and psychiatric disorders
• Highlights emerging cellular models, including iPSC-derived microglia, and novel therapeutic approaches
• Serves as an essential reference for researchers, clinicians, and graduate students in neuroscience and neuroimmunology