Microbiome in Neurological Disease

Dr. Sampson’s primary research interests lie in understanding how the complex interactions between indigenous microbes and the host can shape neurological responses, during neurodegenerative disease and neurological injury. His academic career to date has uniquely positioned him with training across broad topics: microbiology, immunology, genetics, molecular biology, and biochemistry. Following postdoctoral studies at Caltech, with Dr. Sarkis Mazmanian, he utilized his background in bacterial genetics and host-pathogen interactions to explore how indigenous microbes influence Parkinson’s disease (PD). These activities have laid the foundation for his independent career exploring host-microbe interactions at the interface of PD, Alzheimer’s disease (AD) and other neurological illnesses--diseases historically studied within the context of the central nervous system.

• Preface: Unraveling the complex contributions of the microbiome to neurological diseasesTimothy Sampson1. Intersections of the microbiome and early neurodevelopmentHelen Vuong2. Microbiome influences on neuro-immune interactionsMalu G. Tansey and Brittney Otero3. The genomes of Parkinson’s diseaseHaydeh Payami4. Experimental contributions of the microbiome to Parkinson’s diseaseAli Keshavarzian, Christopher Goetz, Deborah Ann Hall, Richard A. Manfready, Robin Voigt and Christopher Forsyth5. The foundations of microbiome contributions to Alzheimer’s diseaseSam Sisodia and Hemraj Dodiya6. Immunologic pathways by which the gut microbiota influences Alzheimer’s diseaseLaurie Cox and Carolin Wasen7. Role of the gut microbiome in Huntington’s DiseaseAnthony Hannan8. The microbiome in multiple sclerosis, from etiology to therapeuticsAshutosh K. Mangalam9. The microbiome and epilepsyElaine Hsiao10. Influence of the microbiome in recovery of traumatic nervous system injuryTimothy Sampson and Adam Hamilton11. Role of the microbiome in chronic and visceral painMichael Burton