Microbial Metabolism and Disease

Häftad, Engelska, 2021

Av Elena L. Paley, USA) Paley, Elena L., PhD (Adjunct Professor at Nova Southeastern University, FL,, Elena L Paley

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Microbiome Metabolic Pathways and Disease provides insight into the interaction of microbial metabolic pathways in the human body and the impact these can have on a variety of diseases. By analyzing these pathways the book seeks to investigate how these metabolic processes can be targeted and manipulated in order to treat various disorders and diseases. Topics covered in the book include microbial shikimate pathways, protein biosynthesis, tryptophan metabolites, microbiome metabolic engineering, fecal microbiota transplantation, and virulence factors. Additionally, a variety of conditions are covered, such as disorders associated with metabolic syndromes, serotonin syndromes, Alzheimer's disease, and Covid-19, providing a detailed overview of how metabolic pathways of microbiome can impact health and disease in the human body.

Explores microbial metabolic pathways in the human body and implications for disease
Investigates specific steps involved in metabolic reactions in the human microbiome, including shikimate pathways and tryptophan pathways
Considers a variety of diseases and disorders, such as Alzheimer's disease, metabolic syndromes, Crohn's disease and Covid-19
Includes analysis of various amino acids and enzymes in microbial and human cells and how these can impact health

Produktinformation

Utgivningsdatum2021-03-18
Mått191 x 235 x 22 mm
Vikt610 g
FormatHäftad
SpråkEngelska
Antal sidor306
FörlagElsevier Science
ISBN9780323884457

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Biologi inom Naturvetenskap och teknik

Dr. Paley is Cofounder of the nonprofit Stop Alzheimers Corp and Founder of Expert Biomed, Inc. She holds a PhD degree in biology with specialization in molecular biology from the Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences in the Laboratory of Lev L. Kisselev. Dr. Paley’s research focuses mainly on protein biosynthesis in biology and diseases and is conducted in collaboration with Harvard University, Brandeis University, the University of Miami, Tel Aviv University, the Institut des Vaisseaux et du Sang (Paris, France), and the University of Texas at San Antonio. She is Adjunct Professor at Nova Southeastern University, FL, United States, and is inventor in patents issued and pending. Dr. Paley has previously published 4 books with Elsevier.

1. Naturally occurring affectors of initial step of protein biosynthesis2. Physicochemical, biochemical and cell biology properties and byproducts of tryptamine and other “trace amines3. Tryptophan metabolites and biogenic amines in physical exercises4. Tryptamine in inflammation and regulation of gene transcription5. Genes encoding mammalian, plant and microbial aromatic amino acid decarboxylase6. Decarboxylases producing tryptamine and other biogenic amines in human microbiome7. Microbial shikimate pathway in diseases8. Biogenic amines in fasting, feeding and stress conditions9. Metabolites of shikimate and tryptophan pathways in Corona virus disease (COVID-19)10. Virulence factors11. Relation of human gut Alzheimer’s disease associated sequence (ADAS) with shikimate pathway metabolites12. Benefits of using fecal microbiota transplantation as treatment have been controversial13. Shikimate pathway enzymes in human microbiome14. Tryptophan operon in human microbiome and inhibitors of tryptophan operon enzymes15. Antibodies to tryptamines16. Cell death in Alzheimer's disease brain and tryptamine-treated cells