This edited work presents generally short biographical studies of 20 quite extraordinary Native American/First Nations women who have contributed creatively and productively to the humanities, science, education, medicine, and community work, each with a sharp focus on social justice. Trafzer, Akers, and Wixon frame these diverse women, born collectively between the late 19th century and 1960, in an introduction centered on the prominence of women and female spiritual principles throughout all Indigenous societies, spanning diverse times and places. Brief sketches of the women are woven throughout the introduction, highlighting the influences of those with whom each woman worked and collaborated. Overall, the book demonstrates how these women addressed and resisted the ravages of infectious disease, medical and educational neglect and malpractice, racism, sexism, assimilation, and other interlocking expressions of discrimination on behalf of their broader communities. The approach of seeking historical understanding through biographical analysis is successful. Recommended. All readers.