Medical Biochemistry

Miriam D. Rosenthal, PhD, is Professor of Biochemistry and Course Director for Medical Biochemistry at Eastern Virginia Medical School. Dr. Rosenthal has extensive experience teaching and developing curricula for both medical and allied health students. Robert H. Glew, PhD, is Emeritus Professor of Biochemistry and Molecular Biology at the University of New Mexico Medical School. Dr. Glew has taught medical biochemistry at three medical schools in the United States and a medical school in West Africa.

• Preface viAcknowledgments ixThe Authors xi1 Introduction to Metabolism 12 Enzymes 113 Digestion and Absorption 384 Glycolysis 585 Pyruvate Dehydrogenase and the Tricarboxylic Acid Cycle 776 Electron Transport and Oxidative Phosphorylation 897 The Pentose Phosphate Pathway 1028 Glycogen 1129 Gluconeogenesis 12610 Fatty Acid Oxidation and Ketones 14111 Fatty Acid Synthesis 16212 Triacylglycerol Transport and Metabolism 17713 Ethanol 19114 Phospholipids and Sphingolipids 19915 Eicosanoids 21816 Glycolipids and Glycoproteins 23117 Cholesterol Synthesis and Transport 24618 Steroids and Bile Acids 27119 Nitrogen Homeostasis 29020 Amino Acids 30521 Sulfur Amino Acid Metabolism 32522 Folate and Vitamin B12 in One-carbon Metabolism 33523 Purines and Pyrimidines 35124 Heme and Iron 37225 Integration of Metabolism 393Index 411

"All the necessary topics are accurately covered, with ample formulae and metabolic pathways, and reasonable clinical references." (ACP News, June 2009)