Mechanotransduction and Mechanosensing

Malgorzata Kloc: Prior to completing her postdoctoral training in Canada, Dr. Kloc was a tenured Associate Professor in the Department of Zoology at the University of Warsaw, Poland. She also served as a Research Associate in the Department of Biology at Carleton University in Ottawa, Canada. While completing her postdoctoral training, Dr. Kloc earned the AHFMR Research Award from the University of Calgary and the MRC Biotechnology Training Award from Dalhousie University. She joined the University of Texas M.D. Anderson Cancer Center as a Research Scientist in the Department of Molecular Genetics in 1987, and became an Associate Professor in the Department of Biochemistry and Molecular Biology there in 2006. Dr. Kloc joined the Houston Methodist Research Institute in 2008. Currently, Dr. Kloc is the Weill Cornell Professor of Cell and Molecular Biology at The Houston Methodist Hospital.Jarek Wosik: After completing his PhD at the Institute of Physics, Polish Academy of Sciences in Poland in 1986, he worked as a Research Scientist at the Research and Development Center for Semiconductors, the Institute of Electron Technology, the Institute of Electronic Materials Technology, and at the Institute of Physics, Polish Academy of Science. In 1987, he moved to Houston and worked at the Department of Electrical and Computer Engineering, University of Houston, and Texas Heart Institute. In 2003, he became a Research Professor at the Department of Electrical & Computer Engineering and Texas Center for Superconductivity, University of Houston. He is a member of the American Physical Society, Material Research Society, and International Society for Magnetic Resonance in Medicine. Since 2001, he has also been a Director of High Frequency Bioengineering Laboratory. His scientific interests include designing magnetic nanoconstructs for the imaging and hyperthermia of tumor cells and neovasculature, water extraction from lunar polar ice by microwave heating, development of noninvasive sensors of metabolic activity, and electromagnetic time-reversal techniques for targeted radiofrequency cancer therapy. He also closely collaborates with Dr. M. Kloc on the magnetic field-induced cytoskeleton alteration to prevent the rejection of transplanted organs.

• Part I. Mechanoperception Molecules and Organelles, Mechanosensing Models and Mechanics Quantification Tools.- Chapter 1. Mechanosensitive TMEM63 Ion Channels: Structure, Gating Mechanism, and Emerging Physiological and Pathological Roles.- Chapter 2. How Touch Triggers Mechanotransduction in Cutaneous Mechanoreceptors.- Chapter 3. Piezo1 in Immune Cells: From Force to Function.- Chapter 4. Podosomes and Mechanical Force.- Chapter 5. Models of Cellular Mechanosensation.- Chapter 6. StrainMapperJ: An Easy-to-Use Digital Image Correlation Toolkit for Exploring and Quantifying the Mechanics of Deforming Tissues.- Part II. Mechanical Effects on Cellular, Organellar, and Molecular Systems.- Chapter 7. Network-Associated Mechanotransduction in Health and Disease.- Chapter 8. Influence of Magneto-Mechanical Stress on Cellular Membranes, Ion Channel Activity, and Gene Expression Dynamics.- Chapter 9. Setting up to Divide – Nuclear Mechanotransduction in the Regulation of Mitosis.- Chapter 10. Forceful Beginnings: Mechanotransduction and Mechanosensation at the Meiotic Cell Nucleus During Gamete Development.- Chapter 11. Modulation of the Mechanosensory Matrisome by Serotonergic Signaling.- Part III. Tissue- and Organ-Specific Mechanotransduction in Health and Disease.- Chapter 12. Ciliary-Mediated Mechanotransduction in Skeletal Development and Diseases.- Chapter 13. Integrating Mechanical Loading, Mechanotransduction and Biological Responses in Musculoskeletal Tissues Across the Lifespan: Regulation Influenced by Cells, Extracellular Matrix and Sex.- Chapter 14. Epigenetic Regulation of RUNX2 in Bone Mechanobiology.- Chapter 15. Mechanobiology of Myelin Generation/Regeneration in Health and Disease.- Chapter 16. Application of Bioactive Natural Compounds to Promote Cell Proliferation and Migration in the Wound Healing Process.