Late-Stage Fluorination of Bioactive Molecules and Biologically-Relevant Substrates

Häftad, Engelska, 2018

AvAl Postigo,Argentina) Postigo, Al (Professor of Organic Chemistry, Universidad de Buenos Aires, Facultad de Farmacia y Bioquimica, Departamento de Quimica Organica"- Buenos Aires

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Late-Stage Fluorination of Bioactive Molecules and Biologically-Relevant Substrates reviews how the use of these techniques on compounds with already known and relevant biological activity can provide new pharmaceutical leads with improved medicinal properties. The fluorination strategies discussed take into account both conventional and novel reagents, including nucleophilic, electrophilic, those of a radical nature, and diverse families of organic compounds, such as (hetero) aromatic rings and aliphatic substrates. Drawing on the authors' expert knowledge, this book provides researchers with a broad set of applicable methods to use in their work.

Highlights the latest developments in the field in a concise volume
Provides details of key fluorinating reagents across diverse families of organic compounds
Explores the current applications and future potential of fluorine in drug development

Produktinformation

Utgivningsdatum2018-09-10
Mått152 x 229 x undefined mm
Vikt570 g
FormatHäftad
SpråkEngelska
Antal sidor390
FörlagElsevier Science
ISBN9780128129586

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Organisk kemi inom Naturvetenskap och teknik

Professor Postigo has worked at the University of Buenos Aires since 2010, where he teaches in the faculty of pharmacy and biochemistry. Having completed his MSc at the University of Buenos Aires, he then took up a place at McMaster University, Canada, where he completed his Doctoral studies in Organic Chemistry. With a particular research interest in fluorination, he has contributed to over 50 publications across the top journals in the field.

1. Introduction and Highlights2. 18F radiolabeling of bioactive compounds 3. Electrophilic and oxidative fluorination of aromatic compounds4. Enantioselective fluorination5. Visible-Light-Mediated C-F bond Activation6. Photocatalytic fluorination reactions7. Fluorination of allylic positions towards the synthesis of fluorinated bioactive compounds8. Difluoromethylation of Bioactive Compounds9. Fluorination of Bioactive Compounds by Electron Transfer Reactions10. Fluorine-Containing Pharmaceuticals and the Phenomenon of Self-Disproportionation of Enantiomers (SDE)

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