Introduction to Cell Mechanics and Mechanobiology

Christopher R. Jacobs (1965–2018) The late Dr. Christopher R. Jacobs was a Professor of Biomedical Engineering at Columbia University, where he served as the director of the Cell and Molecular Biomechanics Lab. A recognized leader in the field, Dr. Jacobs made seminal contributions to the understanding of bone cellular mechanotransduction and computational biomechanics, conducting research that aided in the development of new therapies for age-related bone loss and osteoporosis. His dedication to bridging the disciplines of mechanics and biology continues to influence the field.Hayden Huang Hayden Huang Dr. Hayden Huang is a Senior Engineer in the Center for Science, Technology and Engineering at the U.S. Government Accountability Office (GAO). A biomedical engineer by training, he currently covers issues related to health care and technology to help inform policy makers. Previously, he was a faculty member in the Department of Biomedical Engineering at Columbia University, where his research investigated cell mechanics and cardiovascular physiology. Dr. Huang was a key architect of the original Introduction to Cell Mechanics and Mechanobiology text, drawing on his experience teaching the subject to students from a wide range of engineering and biological backgrounds.Mohammad R. Kaazempur Mofrad Dr. Mohammad Kaazempur Mofrad is a Professor of Bioengineering and Mechanical Engineering at UC Berkeley, where he leads a multidisciplinary research program at the interface of biomechanics, mechanobiology, artificial intelligence, and computational biology. His laboratory investigates how physical forces shape biological structure and function across molecular, cellular, and multicellular scales, and develops computational tools and AI-driven approaches to advance human health.

• Chapter 1 Cell Mechanics as a FrameworkChapter 2 Fundamentals in Cell BiologyChapter 3 Solid Mechanics PrimerChapter 4 Fluid Mechanics PrimerChapter 5 Statistical Mechanics PrimerChapter 6 Cell Mechanics in the LaboratoryChapter 7 Mechanics of Cellular PolymersChapter 8 Polymer Networks and the CytoskeletonChapter 9 Mechanics of the Cell MembraneChapter 10 Adhesion, Migration, and ContractionChapter 11 Cellular MechanotransductionChapter 12 Biomechanics and Mechanobiology of the Nucleus