Introduction to Biophysics and Structural Biology

Nyhet

Häftad, Engelska, 2026

AvJeremy C. Smith

1 449 kr

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Produktinformation

Utgivningsdatum2026-10-19
FormatHäftad
SpråkEngelska
Antal sidor432
FörlagJohn Wiley & Sons Inc
ISBN9781394429226

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1 X-RAY CRYSTALLOGRAPHY 61.1. DIFFRACTION 81.2. THE DNA DOUBLE HELIX 131.3. SOLVING PROTEIN STRUCTURES 201.4. THE PHASE PROBLEM. 291.5. PROBLEM SET 352 NUCLEAR MAGNETIC RESONANCE 391.6. THE NMR PHENOMENON 391.7. CHEMICAL SHIFT. 411.8. J COUPLING 431.9. NUCLEAR OVERHAUSER EFFECT AND 2D NMR 451.10. PROBLEM SET 493 CRYO-ELECTRON MICROSCOPY 551.11. BACTERIORHODOPSIN 551.12. RADIATION DAMAGE 591.13. DIRECT ELECTRON DETECTORS AND VITRIFICATION. 601.14. COMPUTATIONAL ALGORITHMS 611.15. EXAMPLE - A BACTERIAL EFFLUX PUMP 631.16. PROBLEM SET 654 PROTEIN FOLDING 701.17. ANFINSEN’S EXPERIMENTS 701.18. FREE ENERGY, ENTHALPY AND ENTROPY 721.19. HYDROPHOBIC EFFECT 801.20. LEVINTHAL PARADOX and FOLDING FUNNELS 821.21. PROBLEM SET 965 ARTIFICIAL INTELLIGENCE 1011.22. SUPERVISED AND UNSUPERVISED LEARNING 1011.23. DATA 1031.24. FEATURES 1071.25. CLASSICAL ML MODELS. 1081.26. DEEP LEARNING 1111.27. TRAINING THE MODEL 1151.28. ML EXAMPLE – T CELL RECEPTOR SPECIFICITY 1161.29. BAYESIAN AI 1211.30. ALPHAFOLD! 1251.31. PROBLEM SET 1316 MOLECULAR FORCES 36.1 QUANTUM MECHANICS 36.2 MOLECULAR MECHANICS FORCE FIELD 86.3 PROBLEM SET 197 VIBRATIONS AND CONFORMATIONAL TRANSITIONS 237.1 LOW-FREQUENCY VIBRATIONS 287.2 ANHARMONICITY AND CONFORMATIONAL TRANSITIONS 297.3 PROBLEM SET 338 MOLECULAR DYNAMICS SIMULATION 368.1 MD TRAJECTORIES. 368.2 INTERPRETATION OF MD 398.3 CONFORMATIONAL SUBSTATES AND ENERGY LANDSCAPES. 488.4 PROBLEM SET 509 EXPERIMENTS ON DYNAMICS 549.1 NMR 549.2 DYNAMIC NEUTRON SCATTERING 599.3 FLUORESCENCE SPECTROSCOPY 649.4 PROBLEM SETS 7210 LIGAND BINDING. 7610.1 LIGAND BINDING THERMODYNAMICS AND KINETICS. 7610.2 WHAT MAKES A LIGAND BIND. 8310.3 SOLVATION 9110.4 KINETICS 9710.5 PROBLEM SET 10011 ALLOSTERY 10511.1 HEMOGLOBIN 10511.2 RAS AND THE ENSEMBLE MODEL. 11411.3 G-PROTEIN COUPLED RECEPTORS 11911.4 PROBLEM SET 12512 INTRINSICALLY DISORDERED PROTEINS 12912.1 SOLUTION SCATTERING 13012.2 LIQUID-LIQUID PHASE SEPARATION AND BIOLOGICAL CONDENSATES 13912.3 PROBLEM SET 14313 ENZYME CATALYSIS 313.1 CHYMOTRYPSIN 413.2 PROTONATION STATES: MOTIONS OF PROTONS 1213.3 PROBLEM SET 2014 BIOLOGICAL MEMBRANES 2514.1 PHASES AND DOMAINS 2714.2 CHANNELS 3614.3 PROBLEM SET 4315 LIGHT-DRIVEN PROTEINS 4815.1 PHOTOSYNTHESIS 4815.2 RETINAL PROTEINS 6515.3 VISION 6915.5 PROBLEM SET 7316 BIOLOGICAL COMPLEXES AND THE MACHINERY OF LIFE 7816.1 THE RIBOSOME. 8016.2 ATP SYNTHASE. 9116.3 NUCLEAR PORE COMPLEX 9616.4 SPLICEOSOME 10016.5 PROBLEM SET 10517. THE ENVIRONMENT 317.1 MERCURY 417.2 CIRCULAR BIOECONOMY 1517.3 BIOENERGY 1617.4 BIOBASED MATERIALS 3917.5 SYNTHETIC BIOLOGY AND DE NOVO PROTEIN DESIGN 4917.1 CLIMATE 5917.2 PROBLEM SETS 6318. HEALTH 6918.1 STRUCTURE-BASED DRUG DISCOVERY 7318.2 LEAD OPTIMIZATION 8818.3 COVID 19. 9418.4 MODULATING INTERACTIONS BETWEEN MACROMOLECULES 10118.5 DRUG DISCOVERY - THE FUTURE 10518.6 DESIGNING VACCINES 10818.7 PROBLEM SETS 12019. SOME CLOSING THOUGHTS 126Index