This issue of Thoracic Surgery Clinics of North America, guest edited by Dr. Brian E. Louie, is devoted to Innovations in the Management of Foregut Disease. �Dr. Louie has assembled expert authors to review the following topics: Endoscopic approaches to cricopharyngeal myotomy and pyloromyotomy; Options for the challenging hiatus during paraesophageal hernia repair; Endoluminal therapies for esophageal perforations and leaks; Extraluminal approaches to GERD; Advanced endoluminal technologies for Barrett's esophagus - focus on OCT and CLE; Mucosal ablation techniques for Barrett's esophagus and early esophageal cancer; Best practices for training, education and introduction of new techniques for foregut disease management into clinical practice; Per Oral Endoscopic Myotomy (POEM) for Achalasia; Endoscopic resection of tumors of the esophagus; The role of the functional probe in esophageal disease; Enhance the detection of Barrett's esophagus; Endoluminal approaches to GERD; The role of functional fluorescence imaging during esophagectomy; and more!