Injectable Biomaterials

Brent Vernon is Associate Professor of Bioengineering at Arizona State University, USA.

• Contributor contact detailsPart I: Materials and propertiesChapter 1: Designing clinically useful substitutes for the extracellular matrixAbstract:1.1 Introduction: the translational challenge1.2 Design criteria for extracellular matrix (ECM) mimetics1.3 Single-module semi-synthetic extracellular matrices (sECMs) based on hyaluronic acid (HA)1.4 Adding function to hyaluronic acid (HA) matrices1.5 Using injectable synthetic extracellular matrices (sECMs) in vivo1.6 Conclusions and future trendsChapter 2: Designing ceramics for injectable bone graft substitutesAbstract:2.1 Introduction2.2 Rheological properties of bone substitute pastes2.3 Handling and delivery2.4 Mechanical and biological properties of bone substitute pastes2.5 Industrial design2.6 Future trendsChapter 3: Rheological properties of injectable biomaterialsAbstract:3.1 Introduction3.2 Different types of in situ gelling materials: chemical gels, solvent exchange, and physical gels3.3 Shrinkage, swelling, and evaporation3.4 Kinetics and injectability3.5 The role of statistics and uncertainty in rheological characterization3.6 Future trends3.7 Sources of further information and adviceChapter 4: Improving mechanical properties of injectable polymers and compositesAbstract:4.1 Introduction4.2 Mechanical properties and testing4.3 Injectable hydrogels4.4 Non–hydrogel injectable polymers4.5 Conclusion and future trendsPart II: Clinical applicationsChapter 5: Drug delivery applications of injectable biomaterialsAbstract:5.1 Introduction5.2 Solvent exchange precipitating materials5.3 Aqueous solubility change materials5.4 In situ crosslinking or polymerizing materials5.5 Microparticles and nanoparticles5.6 Micelles and liposomes5.7 Polymer-drug conjugates5.8 Conclusion and future trendsChapter 6: Tissue engineering applications of injectable biomaterialsAbstract:6.1 Introduction6.2 Requirements of injectable materials for tissue engineering6.3 Injectable biomaterials: methods of gelation and tissue engineering applications6.4 Injectable composites and applications in tissue engineering6.5 Conclusion and future trends6.7 GlossaryChapter 7: Vascular applications of injectable biomaterialsAbstract:7.1 Introduction7.2 Embolization therapy for vascular conditions7.3 Types of embolic materials7.4 Future trendsChapter 8: Orthopaedic applications of injectable biomaterialsAbstract:8.1 Introduction8.2 Classification8.3 Clinical applications 1: fixation8.4 Clinical applications 2: bone healing8.5 Clinical applications 3: prevention and regeneration8.6 Clinical applications 4: miscellaneous8.7 ConclusionChapter 9: Dental applications of injectable biomaterialsAbstract:9.1 Introduction9.2 Challenges in the application of biomaterials to dentistry9.3 Directly placed tooth-colored materials9.4 Injectable materials in root canal therapy9.5 Injectable calcium phosphate cements9.6 ConclusionChapter 10: Injectable polymeric carriers for gene delivery systemsAbstract:10.1 Introduction10.2 Biological barriers10.3 Nanoparticles10.4 Microspheres10.5 Hydrogels10.6 Small interfering RNA (siRNA)10.7 Conclusion10.8 AcknowledgementsPart III: Technologies and developmentsChapter 11: Environmentally responsive injectable materialsAbstract:11.1 Introduction11.2 Temperature-sensitive polymers11.3 Electrically sensitive polymers11.4 pH-sensitive polymers11.5 Light-sensitive polymers11.6 Biomolecular-sensitive polymers11.7 Other stimuli-sensitive polymers11.8 Conclusion and future trendsChapter 12: Injectable nanotechnologyAbstract:12.1 Introduction12.2 Route of administration and biodistribution of injectable nano-carriers12.3 Diagnostic applications of injectable nano-carriers12.4 Therapeutic applications of injectable nano-carriers12.5 Injectable nanomaterials as matrix precursors12.6 ConclusionsChapter 13: Injectable biodegradable materialsAbstract:13.1 Introduction13.2 Poly(ethylene glycol) (PEG) copolymers13.3 Poloxamer® and Pluronic® gels13.4 Polypeptides13.5 Other thermogelling polymers13.6 Conclusions and future trends13.7 AcknowledgementsChapter 14: Troubleshooting and hurdles to development of biomaterialsAbstract:14.1 Introduction14.2 Material development hurdles14.3 Device development hurdles14.4 Funding challengesChapter 15: Biocompatibility of injectable materialsAbstract:15.1 Introduction15.2 Environmentally responsive biomaterials15.3 Self-assembling biomaterials15.4 Calcium phosphate bone cements15.5 In situ polymerizable and crosslinkable biomaterials15.6 Future trends15.7 Sources of further information and adviceChapter 16: Future applications of injectable biomaterials: the use of microgels as modular injectable scaffoldsAbstract:16.1 Introduction16.2 Background16.3 Potential applications of microgels16.4 Conclusions16.5 Sources of further information and adviceIndex