Del 4 - Advanced Biotechnology
Industrial Biotechnology
Products and Processes
Inbunden, Engelska, 2017
Av Christoph Wittmann, James C. Liao, Germany) Wittmann, Christoph (TU Braunschweig, Braunschweig, USA) Liao, James C. (University of California, Los Angeles
2 859 kr
Produktinformation
- Utgivningsdatum2017-01-25
- Mått173 x 249 x 36 mm
- Vikt1 474 g
- FormatInbunden
- SpråkEngelska
- SerieAdvanced Biotechnology
- Antal sidor640
- FörlagWiley-VCH Verlag GmbH
- ISBN9783527341818
Tillhör följande kategorier
Christoph Wittmann is Director of the Institute of Systems Biotechnology at Saarland University, Saarbrücken, Germany. Having obtained his academic degrees from Braunschweig Technical University, Germany, he was postdoc at Helsinki University, Finland, held chairs for Biotechnology at Münster University, Germany, and for Biochemical Engineering at Braunschweig Technical University and was invited guest professor at Université Rangueil de Toulouse, France, before taking up his present position. He has authored more than 150 scientific publications, more than 20 books and book chapters, holds more than 20 patents and has received several scientific awards, including the Young Scientist Award of the European Federation of Biotechnology, and is board member of various scientific journals.James Liao is the Department Chair of Chemical and Biomolecular Engineering at University of California, in Los Angeles (UCLA), USA. Having obtained his PhD degree from University of Wisconsin, Madison, USA, he started his career at Eastman Kodak Company, before moving to Texas A&M, USA, and then UCLA for his academic career. Professor Liao has received numerous scientific awards, including the Presidential Green Chemistry Challenge Award and the ENI award in renewable energy. He is also a member of the US National Academy of Sciences, National Academy of Engineering, and Academia Sinica in Taiwan.Sang Yup Lee is Distinguished Professor at the Department of Chemical and Biomolecular Engineering at the Korea Advanced Institute of Science and Technology (KAIST). He is currently the Director of the Center for Systems and Synthetic Biotechnology, Director of the BioProcess Engineering Research Center, and Director of the Bioinformatics Research Center. He has published more than 500 journal papers, 64 books and book chapters, and more than 580 patents (either registered or applied). He received numerous awards, including the National Order of Merit, the Merck Metabolic Engineering Award, the ACS Marvin Johnson Award, Charles Thom Award, Amgen Biochemical Engineering Award, Elmer Gaden Award, POSCO TJ Park Prize, and HoAm Prize. He currently is Fellow of American Association for the Advancement of Science, the American Academy of Microbiology, American Institute of Chemical Engineers, Society for Industrial Microbiology and Biotechnology, American Institute of Medical and Biological Engineering, the World Academy of Science, the Korean Academy of Science and Technology, and the National Academy of Engineering of Korea. He is also Foreign Member of National Academy of Engineering USA. He is currently honorary professor of the University of Queensland (Australia), honorary professor of the Chinese Academy of Sciences, honorary professor of Wuhan University (China), honorary professor of Hubei University of Technology (China), honorary professor of Beijing University of Chemical Technology (China), and advisory professor of the Shanghai Jiaotong University (China). Lee is the Editor-in-Chief of the Biotechnology Journal and Associate Editor and board member of numerous other journals. Lee is currently serving as a member of Presidential Advisory Committee on Science and Technology (Korea).Jens Nielsen is Professor and Director to Chalmers University of Technology (Sweden) since 2008. He obtained an MSc degree in Chemical Engineering and a PhD degree (1989) in Biochemical Engineering from the Technical University of Denmark (DTU) and after that established his independent research group and was appointed full Professor there in 1998. He was Fulbright visiting professor at MIT in 1995-1996. At DTU, he founded and directed the Center for Microbial Biotechnology. Jens Nielsen has published more than 350 research papers, co-authored more than 40 books and he is inventor of more than 50 patents. He has founded several companies that have raised more than 20 million in venture capital. He has received numerous Danish and international awards and is member of the Academy of Technical Sciences (Denmark), the National Academy of Engineering (USA), the Royal Danish Academy of Science and Letters, the American Institute for Medical and Biological Engineering and the Royal Swedish Academy of Engineering Sciences.Professor Gregory Stephanopoulos is the W. H. Dow Professor of Chemical Engineering at the Massachusetts Institute of Technology (MIT, USA) and Director of the MIT Metabolic Engineering Laboratory. He is also Instructor of Bioengineering at Harvard Medical School (since 1997). He received his BS degree from the National Technical University of Athens and his PhD from the University of Minnesota (USA). He has co-authored approximately 400 research papers and 50 patents, along with the first textbook on Metabolic Engineering. He has been recognized by numerous awards from the American Institute of Chemical Engineers (AIChE) (Wilhelm, Walker and Founders awards), American Chemical Society (ACS), Society of industrial Microbiology (SIM), BIO (Washington Carver Award), the John Fritz Medal of the American Association of Engineering Societies, and others. In 2003 he was elected member of the National Academy of Engineering (USA) and in 2014 President of AIChE.
- List of Contributors XXIAbout the Series Editors XXXIPreface XXXIIIPart I Enabling and Improving Large-Scale Bio-production 11 Industrial-Scale Fermentation 3Hans-Peter Meyer, Wolfgang Minas, and Diego Schmidhalter1.1 Introduction 31.2 Industrial-Scale Fermentation Today 51.3 Engineering and Design Aspects 181.4 Industrial Design Examples 361.5 Cost Analysis for the Manufacture of Biotechnological Products 421.6 Influence of Process- and Facility-Related Aspects on Cost Structure 47Acknowledgments 51References 522 Scale-Down: Simulating Large-Scale Cultures in the Laboratory 55Alvaro R. Lara, Laura A. Palomares, and Octavio T. Ramírez2.1 Introduction 552.2 Heterogeneities at Large Scale and the Need for Scaling Down 562.3 Bioreactor Scale-Down 582.4 Tools to Study Cell Responses to Environmental Heterogeneities 622.5 Physiological Effects of Environmental Heterogeneities 682.6 Improvements Based on Scale-Down Studies: Bioreactor Design and Cell Engineering 722.7 Perspectives 73Acknowledgment 74References 743 Bioreactor Modeling 81Rob Mudde, Henk Noorman, and Matthias Reuss3.1 Large-Scale Industrial Fermentations: Challenges for Bioreactor Modeling 813.2 Bioreactors 833.3 Compartment and Hybrid Multizonal/Computational Fluid Dynamics Approaches for the Description of Large-Scale Bioreactor Phenomena 893.4 Computational Fluid Dynamics Modeling: Unstructured Continuum Approach (Euler–Euler) 923.5 Computational Fluid Dynamics Modeling: Structured Segregated Approach (Euler–Lagrange) 1143.6 Conclusion 1223.7 Outlook 122References 1244 Cell Culture Technology 129Ralf Pörtner, Uwe Jandt, and An-Ping Zeng4.1 Introduction 1294.2 Overview of Applications for Cell Culture Products and Tissue Engineering 1294.3 Fundamentals 1314.4 Bioreactors for Cell Culture 1404.5 Downstream 1464.6 Regulatory and Safety Issues 1504.7 Conclusions and Outlook 152References 152Part II Getting Out More: Strategies for Enhanced Bioprocessing 1595 Production of Fuels and Chemicals from Biomass by Integrated Bioprocesses 161Tomohisa Hasunuma and Akihiko Kondo5.1 Introduction 1615.2 Utilization of Starchy Biomass 1635.3 Utilization of Lignocellulosic Biomass 1665.4 Conclusions and Perspectives 177Acknowledgment 177References 1786 Solid-State Fermentation 187Reeta Rani Singhania, Anil Kumar Patel, Leya Thomas, and Ashok Pandey6.1 Introduction 1876.2 Fundamentals Aspects of SSF 1886.3 Factors Affecting Solid-State Fermentation 1936.4 Scale-Up 1966.5 Product Recovery 1986.6 Bioreactor Designing 1986.7 Kinetics and Modeling 2006.8 Applications 2016.9 Challenges in SSF 2026.10 Summary 203References 2037 Cell Immobilization: Fundamentals, Technologies, and Applications 205Xumeng Ge, Liangcheng Yang, and Jianfeng Xu7.1 Introduction 2057.2 Fundamentals of Cell Immobilization 2067.3 Immobilization with Support Materials 2077.4 Self-Immobilization 2127.5 Immobilized Cells and their Applications 2187.6 Bioreactors for Cell Immobilization 2257.7 Challenges and Recommendations for Future Research 2297.8 Conclusions 230References 231Part III Molecules for Human Use: High-Value Drugs, Flavors, and Nutraceuticals 2378 Anticancer Drugs 239Le Zhao, Zengyi Shao, and Jacqueline V Shanks8.1 Natural Products as Anticancer Drugs 2398.2 Anticancer Drug Production 2398.3 Important Anticancer Natural Products 2438.4 Prospects 261References 2639 Biotechnological Production of Flavors 271Maria Elisabetta Brenna and Fabio Parmeggiani9.1 History 2719.2 Survey on Today’s Industry 2729.3 Regulations 2739.4 Flavor Production 2749.5 Biotechnological Production of Flavors 2759.6 Vanillin 2779.7 2-Phenylethanol 2819.8 Benzaldehyde 2839.9 Lactones 2859.10 Raspberry Ketone 2899.11 Green Notes 2919.12 Nootkatone 2939.13 Future Perspectives 296References 29710 Nutraceuticals (Vitamin C, Carotenoids, Resveratrol) 309Sanjay Guleria, Jingwen Zhou, and Mattheos A.G. Koffas10.1 Introduction 30910.2 Vitamin C 31010.3 Carotenoids 31710.4 Resveratrol 32310.5 Future Perspectives 329References 330Part IV Industrial Amino Acids 33711 Glutamic Acid Fermentation: Discovery of Glutamic Acid-Producing Microorganisms, Analysis of the Production Mechanism, Metabolic Engineering, and Industrial Production Process 339Takashi Hirasawa and Hiroshi Shimizu11.1 Introduction 33911.2 Discovery of the Glutamic Acid-Producing Bacterium C.glutamicum 34011.3 Analysis of the Mechanism of Glutamic Acid Production by C. glutamicum 34211.4 Metabolic Engineering of C. glutamicum for Glutamic Acid Production 35011.5 Glutamic Acid Fermentation by Other Microorganisms 35211.6 Industrial Process of Glutamic Acid Production 35311.7 Future Perspectives 354References 35512 L-Lysine 361Volker F.Wendisch12.1 Uses of L-Lysine 36112.2 Biosynthesis and Production of L-Lysine 36312.3 The Chassis Concept: Biotin Prototrophy and Genome Reduction 37412.4 L-Lysine Biosensors for Strain Selection and on-Demand Flux Control 37712.5 Perspective 380References 380Part V Bio-Based Monomers and Polymers 39113 Diamines for Bio-Based Materials 393Judith Becker and Christoph Wittmann13.1 Introduction 39313.2 Diamine Metabolism in Bacteria 39513.3 Putrescine – 1,4-Diaminobutane 39513.4 Cadaverine – 1,5-Diaminopentane 39913.5 Conclusions and Perspectives 403References 40414 Microbial Production of 3-Hydroxypropionic Acid 411Yokimiko David, Young Hoon Oh, Mary Grace Baylon, Kei-Anne Baritugo, Jeong Chan Joo, Cheol Gi Chae, You Jin Kim, and Si Jae Park14.1 Introduction 41114.2 3-HP Obtained from Native Producers 41314.3 Synthesis of 3-HP from Glucose 41714.4 Synthesis of 3-HP from Glycerol 42114.5 Bridging the Gap Between Glucose and Glycerol in 3-HP Production 43714.6 Other Strains for 3-HP Production from Glycerol 43814.7 Limitations of 3-HP Synthesis 44014.8 Conclusions and Future Prospects 442Acknowledgments 443References 44415 Itaconic Acid – An Emerging Building Block 453Matthias G. Steiger, Nick Wierckx, Lars M. Blank, Diethard Mattanovich, and Michael Sauer15.1 Background, History, and Economy 45315.2 Biosynthesis of Itaconic Acid 45515.3 Production Conditions for Itaconic Acid 45915.4 Physiological Effects and Metabolism of Itaconic acid 46115.5 Metabolic Engineering for Itaconic Acid Production 46215.6 Outlook 467Acknowledgments 468References 469Part VI Top-Value Platform Chemicals 47316 Microbial Production of Isoprene: Opportunities and Challenges 475Huibin Zou, Hui Liu, Elhussiny Aboulnaga, Huizhou Liu, Tao Cheng, and Mo Xian16.1 Introduction 47516.2 The Milestones of Isoprene Production 47616.3 Microbial Production of Isoprene: Out of the Laboratory 47716.4 Main Challenges for Bioisoprene Production 48916.5 Future Prospects 491Acknowledgments 498References 49817 Succinic Acid 505Jung Ho Ahn, Yu-Sin Jang, and Sang Yup Lee17.1 Introduction 50517.2 Development of Succinic Acid Producers and Fermentation Strategies 50617.3 Succinic Acid Recovery and Purification 53317.4 Summary 536Acknowledgments 537References 537Part VII Biorenewable Fuels 54518 Ethanol: A Model Biorenewable Fuel 547Tao Jin, Jieni Lian, and Laura R. Jarboe18.1 Introduction 54718.2 Metabolic Engineering: Design, Build, Test, Learn 54918.3 Biomass Deconstruction 56318.4 Closing Remarks 564Acknowledgments 564References 56419 Microbial Production of Butanols 573Sio Si Wong, Luo Mi, and James C. Liao19.1 Introduction 57319.2 A Historical Perspective of n-Butanol Production 57419.3 ABE Fermentation 57519.4 n-Butanol Production in Non-native Producers 58019.5 Isobutanol Production 58319.6 Summary and Outlook 589Acknowledgments 589References 589Index 597