Heterocycles in Natural Product Synthesis

Krishna C. Majumdar is a Professor of Chemistry at the University of Kalyani in India. Having obtained his B.Sc and M. Sc. From the University of Calcutta, and Ph. D. from the University of Idaho (USA), he spent five yearsas a post-doctoral fellow at the University of Idaho and Alberta before taking up faculty position at the University of Kalyani. His research interests centre around the synthesis of bioactive heterocycles. His recent interests include the synthesis of liquid crystalline compounds. Professor Majumdar has authored over 330 publications including numerous reviews, book chapters etc and is a recipient of the Chemical Research Society of India medal and Indian Chemical Society award. He is a fellow of the West Bengal Academy of Science and Technology. Shital K. Chattopadhyay is a Professor of Chemistry in the University of Kalyani, India. He obtained his Ph. D. degree from the University of Kalyani (Professor K. C. Majumdar) and then carried out his post-doctoral works in the University of East Anglia (Professor A. McKillop), U.K., Nottingham University (Professor G. Pattenden), U.K., Umea University (Professor T. Frejd), Sweden and Indian Institute of Science, Bangalore (Professor G. Mehta), India, working on total synthesis of complex heterocyclic natural products for nearly six years. His research interests surround on asymmetric synthesis of heterocyclic natural products of biological interest. He is recipient of the European Union research bursuary and Royal Society (U. K.) visiting fellowship. He has co-authored nearly seventy publications and has published one review article.

• Preface PART I: Strained Heterocycles in the Synthesis of Natural Products AZIRIDINES IN NATURAL PRODUCT SYNTHESISIntroductionSynthesis of Natural Products Containing Aziridine UnitsSynthesis of Natural Products Involving the Transformation of an Aziridine MoietyConclusions AZETIDIINE AND ITS DERIVATIVESIntroductionStructural Description of AzetidinesSynthetic Methodologies for the Formation of Azetidine RingsSynthesis of Mugineic AcidsSynthesis of PenaresidinsStructural Description of Azetidin-2-onesSynthetic Methodologies for the Formation of Azetidin-2-onesSynthesis of PenicillinSynthesis of CephalosporinConclusion EPOXIDES AND OXETANESIntroductionEpoxides in Natural Product SynthesisOxetane in Natural Product SynthesisConclusion PART II: Common Ring Heterocycles in Natural Product Synthesis FURAN AND ITS DERIVATIVESIntroductionNatural Products Containing the Furan RingFuran Derivatives as Reagents in the Synthesis of Natural ProductsSummary PYRAN AND ITS DERIVATIVESIntroductionApplication of Pyran Moieties in the Synthesis of Natural ProductsConclusion PYRROLE AND ITS DERIVATIVESIntroductionSynthesis of Pyrrole Natural ProductsSynthesis of Non-pyrrole Natural Products from Pyrrole DerivativesConclusion INDOLES AND INDOLIZIDINESIntroductionApplications of Indoles and Indolizidines in the Synthesis of Natural ProductsConclusion PYRIDINE AND ITS DERIVATIVESIntroductionApplication of the Pyridine Moiety in the Synthesis of Natural ProductsConclusion QUINOLINES AND ISOQUINOLINESIntroductionApplication of Quinolines and Isoquinolines in the Synthesis of Natural ProductsConclusion CARBAZOLES AND ACRIDINESIntroduction to CarbazolesTotal Synthesis of Carbazole AlkaloidsIntroduction to AcridinesSynthesis of Acridines and Acridones THIOPHENE AND OTHER SULFUR HETEROCYCLESIntroductionSynthesis of Natural Products Containing ThiopheneSynthesis of Natural Products Containing Other Sulfur HeterocyclesConclusion OXAZOLE AND ITS DERIVATIVESIntroductionMono-OxazolesUnconnected Bis- and Tris-OxazolesCyclic Polyheterocyclic Metabolites Containing Single Oxazole ResiduesConjugated Bis-OxazolesTris- and Poly-Oxazoles THIAZOLINE AND THIAZOLE AND THEIR DERIVATIVESIntroductionGeneral Methods for the Synthesis of Thiazoline and Thiazole DerivativesThiazole and Thiazoline-Containing Natural ProductsConclusions PYRIMIDINE AND IMIDAZOLEGeneral IntroductionPyrimidine-Based Natural ProductsImidazole-Based Natural ProductsConclusion PART III: Natural Products Containing Medium and Large Ring-Sized Heterocyclic Systems OXEPINES AND AZEPINESIntroductionSynthesis of the Heterocyclic Core of Selected Natural Products Containing OxepinesSynthesis of the Heterocyclic Core of Selected Natural Products Containing AzepinesSynthesis of the Heterocyclic Core of Selected Natural Products Containing OxazapinesConclusion BIOACTIVE MACROCYCLIC NATURAL PRODUCTSGeneralNatural Products Containing AzolesPyridine- and Piperidine-Containing Natural ProductsIndole- and Imidazole-Containing Natural ProductsPyran- and Furan-Containing Natural ProductsPiperazic Acid-Containing Natural ProductsMixed Heterocyclic SystemsConclusions

“As such, this book is certain to have value to scientists in multiple fields, from natural product synthesis chemists to researchers in the pharmaceutical industry, and this reviewer is glad that these editors and all the contributing authors devoted time to creating such an important text.”  (Angewandte Chemie, 2012)