In this issue of Heart Failure Clinics, guest editor Dr. Rodolfo Citro brings his considerable expertise to the topic of Heart and Brain: A Complex Interaction. Understanding the heart-brain relationship is crucial for managing conditions affecting both organs, leading to innovative diagnostic and therapeutic strategies for improved patient outcomes. In this issue, top experts discuss the heart-brain anatomical and physiological relationship; neurogenic cardiac syndromes; neurohumoral axis and stress cardiomyopathy; structural and functional brain features in Takotsubo syndrome; psychological stress and coronary artery syndromes; and more.
