While the security of a community or state is undermined directly or indirectly if its individuals have poor health, the state-centric violence paradigm failed to include public health problems such as epidemics and its aftermaths. Through a review of member states’ health care systems of the Mano River Union (MRU) in West Africa, this book articulates nicely the challenges related to leadership and governance; health workforce; medical products, vaccines and technologies; information; financing; and services delivery in the sub-region. From a human security perspective, the book, grounded in rich empirical illustrations, demonstrates that protecting and empowering the populations is vital to accomplishing and preserving their utmost level of health and well-being and calls therefore for creative ways to realize, protect, enforce and promote the right to health.