Handbook of Industrial Crystallization

Allan S. Myerson is Professor of the Practice of Chemical Engineering in the Department of Chemical Engineering at the Massachusetts Institute of Technology. Professor Myerson's research focuses on separations processes in the chemical and pharmaceutical industry with an emphasis on crystallization from solution, nucleation, polymorphism and pharmaceutical manufacturing. Professor Myerson has received a number of award including the American Chemical Society Award in Separations Science and Technology (2008), the AIChE Separations Division Clarence G. Gerhold Award (2015) and the AICHE Process Development Division Excellence in Process Development Research Award (2015). Deniz Erdemir is a Principal Scientist at Bristol-Myers Squibb (BMS). Dr Erdemir's research focus lies at the drug substance/drug product interface with emphasis on crystal polymorphism and design of materials via particle engineering to enable robust drug products. She has published twelve papers and she is the inventor on two US patents. Alfred Y. Lee is an Associate Principal Scientist in the Department of Process Research and Development at Merck & Co., Inc. Prior to his current position, Dr Lee was a Principal Scientist at GlaxoSmithKline PLC. Dr. Lee's scientific interests are in the area of crystal engineering, crystallization process development, materials characterization, polymorphism, and the physical chemistry of solids.

• 1. Solutions and solution properties Jennifer Moffitt Schall and Allan S. Myerson; 2. Crystals and crystal growth Alfred Y. Lee, Deniz Erdemir and Allan S. Myerson; 3. Crystal nucleation Deniz Erdemir, Alfred Y. Lee and Allan S. Myerson; 4. The influence of impurities and additives on crystallization Lucréce Hèlène Nicoud and Allan S. Myerson; 5. Molecular modeling applications in crystallization Keith Chadwick, Jie Chen, Erik E. Santiso and Bernhardt L. Trout; 6. Crystallization process analysis by population balance modeling Åke C. Rasmuson; 7. Selection and design of industrial crystallizers Herman J. Kramer and Richard Lakerveld; 8. Precipitation processes Piotr Karpiński and J. Bałdyga; 9. Melt crystallization Joachim Ulrich and Torsten Stelzer; 10. Crystallizer mixing: understanding and modeling crystallizer mixing and suspension flow Daniel A. Green; 11. Monitoring and advanced control of crystallization processes Zoltan K. Nagy, Mitsuko Fujiwara and Richard D. Braatz; 12. Batch crystallization Piotr Karpiński and Jerzy Baldyga; 13. Crystallization in the pharmaceutical industry Simon N. Black; 14. Crystallization of proteins Peter G. Vekilov; 15. Crystallization in foods Richard W. Hartel; 16. Precipitation and crystallization of pigments Lars Vicum, Marco Mazzotti and Martin Iggland.

'In its experimental and theoretical aspects, the present handbook is well organized. One of the major strengths of the book is the fact that, despite its wide range of topics, the editors succeeded in combining the different contributions in a very coherent framework. The book represents a good overview of knowledge of the widespread field of industrial crystallization. I recommend the book to scientists and engineers working in this field.' Klaus-Werner Benz, Journal of Applied Crystallography